| t(8,21)易位急性髓细胞性白血病免疫学表型分析 |
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| 引用本文： | 华东,夏学鸣,李建勇,王爱青,谢新. t(8,21)易位急性髓细胞性白血病免疫学表型分析[J]. 苏州大学学报(自然科学版), 1997, 0(3) |
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| 作者姓名： | 华东 夏学鸣 李建勇 王爱青 谢新 |
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| 作者单位： | 苏州医学院附属一院血液科!215006，无锡第四人民医院，苏州医学院附属一院血液科!215006，苏州医学院附属一院血液科!215006，苏州医学院校工业总公司重点实验室，苏州医学院附属一院血液科!215006 |
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| 摘 要： | 用流式细胞仪检测21例t（8；21）易位急性髓细胞性白血病细胞的免疫学表型，并与无t（8；21）易位急性髓细胞白血病（M2）病人比较．结果：t（8；21） 组与t（8；21）-组CD1，阳性率分别为62％、9％（P＜0．01）．CD34阳性率分别为76.2％、36％（P＜0．05），t（8；21） 组中皆无表达CD7，而t（8；21）-组中CD7阳性率为27．2％（P＜0．05）；两组间CD15、CD13、CD33、CD10表达无显著差异．提示t（8；21）急性髓细胞白血病有独特的免疫学表型特点，对形态学分类法难以分类的急性白血病诊断有一定的价值．
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| 关 键 词： | 白血病 髓细胞性 急性 免疫学表型 染色体 |
The Analysis of Immunophenotype in Acute Myeloid Leukemia with t(8; 21) Translocation |
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| Hua Dong,Xia Xuemin.. The Analysis of Immunophenotype in Acute Myeloid Leukemia with t(8; 21) Translocation[J]. Suzhou University Journal of Medical Science, 1997, 0(3) |
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| Authors: | Hua Dong Xia Xuemin. |
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| Abstract: | Immunophenotyping in 21 cases of acute myeloid leukemia (AML) with t(8; 21) translocation was dtected on flow cytometry and was compared with AML(M2) without t(8 ; 21) translocation. The results showed CD19 positivity rate in t (8; 21 ) group and t (8; 21 )- group were 62%, 9% respectively (p < 0. 01 ) CD34 positivity rate were 76. 2%, 4% respectively (P). ) % ). There was no signficant difference between CD15, CD13 and CD33 expression. CD7 expression wasn' t detected in t (8 ; 21 ) group. The study suggested that AML with t (8 ; 21 )translocation had unique immunophenotyping characteristics which were of some diagnosis value to AML that was difficult to classisify in FAB. |
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| Keywords: | Leukemia myeloid acute immunophenotype t(8 21) translocation |
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