| 拉米夫定、恩替卡韦治疗慢性重型乙型肝炎疗效比较 |
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| 引用本文： | 应桂花. 拉米夫定、恩替卡韦治疗慢性重型乙型肝炎疗效比较[J]. 临床医学, 2007, 27(11): 15-17 |
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| 作者姓名： | 应桂花 |
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| 作者单位： | 陕西省铜川市矿务局中心医院感染科,铜川,727000 |
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| 摘 要： | 目的 评价拉米夫定、恩替卡韦治疗慢性重型乙型肝炎的短期疗效.方法 72例慢性重型乙型肝炎患者随机分为拉米夫定组42例和恩替卡韦组30例.拉米夫定组给予拉米夫定100 mg,每天1次口服,恩替卡韦组给予恩替卡韦O.5 mg,每天1次,两组的基础护肝治疗相同,共治疗24周.结果 恩替卡韦治疗组血清HBV DNA的阴转率为60%,明显高于拉米夫定组,且丙氨酸转氨酶、总胆红素水平均明显好于拉米夫定组(P《0.05).结论 短期应用恩替卡韦治疗慢性重型乙型肝炎疗效明显优于拉米夫定.
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| 关 键 词： | 慢性重型肝炎 拉米夫定 恩替卡韦 |
| 修稿时间： | 2007-03-13 |
Comparative study on clinical effects of lamivudine and entecavir in treatment of chronic hepatitis gravis |
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| YING Guihua. Comparative study on clinical effects of lamivudine and entecavir in treatment of chronic hepatitis gravis[J]. Clinical Medicine, 2007, 27(11): 15-17 |
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| Authors: | YING Guihua |
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| Affiliation: | Department of Infectious, the Coal - Mine Central Hospital of Tongchuan, Tongchuan 727000, Shanxi |
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| Abstract: | Objective To evaluate the short-term of lamivudine and entecavir in treatment of chronic hepatitis gravis.Methods Seventy-two patients with chronic hepatitis gravis were divided into lamivudine group and entecavir group.One group received lamivudine for 24 weeks,the other received entecavir for 24 weeks,and patients in both groups received conventional treatment.Results After 24 weeks of treatment,the negativity of HBV DNA in entecavir group was significantly higher than that in lamivudine group.ALT and TBIL decrease levels in entecavir group was significantly higher than that in lamivudine group.Conclusion The short-term efficacy of entecavir treatment for chronic hepatitis gravis is better than lamivudine treatment. |
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| Keywords: | Chronic hepatitis gravis Entecavir Lamivudine |
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