| "脾虚"大鼠胃黏膜组织一氧化氮含量及补中益气汤的作用 |
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| 引用本文： | 许琦,刘晓秋,王建华,唐惠琼,王汝俊."脾虚"大鼠胃黏膜组织一氧化氮含量及补中益气汤的作用[J].中药药理与临床,2003,19(1):7-8. |
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| 作者姓名： | 许琦 刘晓秋 王建华 唐惠琼 王汝俊 |
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| 作者单位： | 1. 广州中医药大学2000级博士生
2. 广州中医药大学脾胃研究所 |
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| 基金项目： | 广东省自然科学基金(No . 980 6 40 )，国家自然科学基金资助 (No . 3 0 2 71 6 50 ) |
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| 摘 要： | 目的：研究“脾虚”大鼠胃黏膜组织一氧化氮（NO）含量的变化及补中益气汤的作用。方法：采用Griess试剂法和紫外分光光度法检测胃黏膜组织的一氧化氮代谢产物（NO2^-和NO3^-）和过氧化亚硝酸（ONOO^-）。结果：大黄“脾虚”大鼠胃黏膜组织中NO3^-、iNOS及ONOO^-水平均低于正常大鼠，经补中益气汤治疗后能恢复到接近正常水平。结论：“脾虚”大鼠胃黏膜组织一氧化氮（NO）含量低于正常，补中益气汤能升高“脾虚”大鼠胃黏膜组织中NO的含量。
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| 关 键 词： | 大黄脾虚模型 胃黏膜 一氧化氮 一氧化氮合酶 过氧化亚硝酸 补中益气汤 中药 药理 |
Effect of Buzhong Yiqi Tang (补中益气汤) on the nitric oxide in gastric mucosa in rat with deficiency of the Pi |
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| Xu Qi,Liu Xiaoqiu,Wang Jianhua,Tang Huiqiong,Wang Rujun.Effect of Buzhong Yiqi Tang (补中益气汤) on the nitric oxide in gastric mucosa in rat with deficiency of the Pi[J].Pharmacology and Clinics of Chinese Materia Medica,2003,19(1):7-8. |
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| Authors: | Xu Qi Liu Xiaoqiu Wang Jianhua Tang Huiqiong Wang Rujun |
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| Abstract: | Objective: To study the effect of Buzhong Yiqi Tang on the level of nitric oxide (NO) in gastric mucosa in rats with deficiency of the Pi. Methods: The amount of nitric oxide (NO) is detected by the concentration of nitrite and nitrate(NO 2 -and NO 3 -), constitutive and inducible nitric oxide synthase (cNOS and iNOS), and peroxinitrites (ONOO) in gastric mucosa in rats. Results: The level of NO 3 -?iNOS and ONOO - is lower in rats with deficiency of the Pi than in normal rats. The level almost reversed after treatment with Buzhong Yiqi Tang. Conclusion: There is low level of NO in gastric mucosa in rats with deficiency of the Pi. Buzhong Yiqi Tang can increase the level of it. |
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| Keywords: | rat with deficiency of the Pi gastric mucosa nitric oxide nitric oxide synthase peroxinitrites Buzhong Yiqi Tang |
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