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| 硒对氟致大鼠脂质过氧化拮抗作用 | |
| 引用本文： | 李贤相,翟大耀,王玉林,吴克里,杨克敌,王桂珍,王爱国. 硒对氟致大鼠脂质过氧化拮抗作用[J]. 中国公共卫生, 2004, 20(1): 15-16 |
| 作者姓名： | 李贤相 翟大耀 王玉林 吴克里 杨克敌 王桂珍 王爱国 |
| 作者单位： | 1. 安徽省安庆市疾病预防控制中心,246001 2. 华中科技大学同济医学院环境卫生教研室 |
| 摘 要： | 目的 研究氟与脂质过氧化的关系，硒对氟引起的脂质过氧化的影响。方法 将40只SD大鼠随机分为4组。按对照、氟、硒、硒氟不同饮水饲养8周，观察硒对氟引起大鼠血清、肝、肾、心、睾丸脂质过氧化的影响。结果 与对照组相比．加氟组全血谷胱甘肽过氧化物酶(GSH-Px)显著下降，血清、肝、肾、心、睾丸的脂质过氧化(LPO)含量水平明显升高；加硒组增强机体抗氧化功能，提高全血GSH-Px活性，降低机体LPO含量。结论 可通过补硒来拮抗氟引起的脂质过氧化。 |
| 关 键 词： | 氟 硒 谷胱甘肽过氧化物酶 脂质过氧化 |
| 文章编号： | 1001-0580(2004)01-0015-02 |
| 修稿时间： | 2003-05-14 |
Antagonistic effects of selenium on fluoride-induced lipid peroxide in rats |
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| LI Xian xiang,ZHAI Da yao,WANG Yu lin,et al.. Antagonistic effects of selenium on fluoride-induced lipid peroxide in rats[J]. Chinese Journal of Public Health, 2004, 20(1): 15-16 | |
| Authors: | LI Xian xiang ZHAI Da yao WANG Yu lin et al. |
| Affiliation: | LI Xian xiang,ZHAI Da yao,WANG Yu lin,et al.Anqing Cen ter for Disease Control and Prevention |
| Abstract: | ObjectiveTo study the relation between fluorine and lipi d peroxide,and the effects of selenium of fluoride-induced lipid peroxide.Methods40 rats were divided into four groups(control,flu orine,selenium,Se-fluorine by drinking)in random and fed for eight weeks.To obse rve the effects of selenium of fluoride-induced lipid peroxide in blood serum,li ver,kidney,heart,testis in rats.ResultsThe glutathione peroxidase(GSH-Px) in whole blood of the fluorine group was significant decrease,and the obvious increase of lipi d peroxide(LPO) levels in blood serum,liver,kidney,heart,testis can be observed. Adding the selnium in drinking can increase the power of anti-oxidation,as well as increase the activities of GSH-Px and decrease the levels of LPO.ConclusionSelenium can antagon fluoride-induced lipid p eroxide. |
| Keywords: | fluorine selenium GSH-Px lipid peroxide |
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