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| 以马兜铃酸为例探讨中药毒性成分限量标准制定方法 | |
| 引用本文： | 李功辉,陈莎,章军,王跃生,程锦堂,刘安. 以马兜铃酸为例探讨中药毒性成分限量标准制定方法[J]. 中国中药杂志, 2017, 42(4): 800-804 |
| 作者姓名： | 李功辉 陈莎 章军 王跃生 程锦堂 刘安 |
| 作者单位： | 中国中医科学院 中药研究所, 北京 100700;江西中医药大学, 江西 南昌 330004,中国中医科学院 中药研究所, 北京 100700,中国中医科学院 中药研究所, 北京 100700,中国中医科学院 中药研究所, 北京 100700;江西中医药大学, 江西 南昌 330004,中国中医科学院 中药研究所, 北京 100700,中国中医科学院 中药研究所, 北京 100700 |
| 基金项目： | 国家"重大新药创制"科技重大专项（2014ZX09304307001） |
| 摘 要： | 中药安全性问题引起越来越多的关注,中药毒性成分的限量标准制定迫在眉睫。该文分析了中药毒性成分限量标准研究的现状和问题,归纳和评述了相关毒性成分的限量标准研究方法,提出了中药中毒性成分的限量标准理论值计算方法,并以马兜铃酸为例,制定了其在中药材中的限量标准,以期为中药毒性成分的限量标准研究提供有益参考。 |
| 关 键 词： | 马兜铃酸 限量标准 中药 毒性成分 |
| 收稿时间： | 2016-10-24 |
Explore a method for formulation of limit standard of toxic components in traditional Chinese medicine: aristolochic acid as a case study |
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| LI Gong-hui,CHEN Sh,ZHANG Jun,WANG Yue-sheng,CHENG Jin-tang and LIU An. Explore a method for formulation of limit standard of toxic components in traditional Chinese medicine: aristolochic acid as a case study[J]. China Journal of Chinese Materia Medica, 2017, 42(4): 800-804 | |
| Authors: | LI Gong-hui CHEN Sh ZHANG Jun WANG Yue-sheng CHENG Jin-tang LIU An |
| Affiliation: | Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China,Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China,Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China,Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China,Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China |
| Abstract: | It is urgent to establish the limit standard of toxic components of Chinese herbal medicine, since the safety of traditional Chinese medicine (TCM) has attracted more and more attention.This paper analyzes the present situation and problems in the study of the limit standard of toxic components of Chinese herbal medicine. In addition, the current methods for setting the limit standards of toxic ingredients of TCM are reviewed in this paper, and we also propose a theoretical calculation method for setting the limit standards of toxic ingredients of TCM. Employing aristolochic acid as a case study, we formulate the limit standard of toxic components of Chinese herbal medicine. We believe this paper would provide some useful suggesting for formulating limits standard of toxic components of TCM. |
| Keywords: | aristolochic acid limit standard traditional Chinese medicine (TCM) toxic components |
| 本文献已被 CNKI 等数据库收录！ | |