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| 肝愈胶囊对实验性肝损伤的保护作用 | |
| 引用本文： | 柴秋彦,韩文兰,杨文彬,李百强,史向华,崔吉利. 肝愈胶囊对实验性肝损伤的保护作用[J]. 中药新药与临床药理, 2004, 15(2): 98-101 |
| 作者姓名： | 柴秋彦 韩文兰 杨文彬 李百强 史向华 崔吉利 |
| 作者单位： | 山西省医药研究所药理室,太原,030006 |
| 摘 要： | 目的观察肝愈胶囊对实验性肝损伤的保护作用.方法以四氯化碳(CCl4)、D-半乳糖胺(D-Galn)建立小鼠急性实验性肝损伤模型、以四氯化碳加复合因子建立大鼠实验性肝硬化模型,观察对多种生化检测指标的影响.结果肝愈胶囊可明显降低由CCl4、D-Galn引起急性肝损伤小鼠的血清谷丙转氨酶活性升高,减轻病理组织学的改变;可降低四氯化碳加复合因子造成的慢性肝损伤模型大鼠的谷丙转氨酶、谷草转氨酶活性,降低肝组织胶原蛋白含量,减轻肝硬化程度.结论肝愈胶囊对实验性肝损伤有明显的保护作用. |
| 关 键 词： | 肝愈胶囊 实验性肝损伤 保肝作用 药效学 |
| 文章编号： | 1003-9783(2004)02-0098-04 |
Protective Effect of Ganyu Capsule on Experimental Hepatic Injury |
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| CHAI Qiuyan,HAN Wenlan,YANG Wenbing,LI Baiqiang,SHI Xianghua,CUI Jili. Protective Effect of Ganyu Capsule on Experimental Hepatic Injury[J]. Traditional Chinese Drug Research & Clinical Pharmacology, 2004, 15(2): 98-101 | |
| Authors: | CHAI Qiuyan HAN Wenlan YANG Wenbing LI Baiqiang SHI Xianghua CUI Jili |
| Abstract: | Objective To investigate the protective effect of Ganyu capsule on the experimental hepatic injury in mice and rats.Methods Acute hepatic injury was induced by intraperitoneal injection of 0.1 ?l4 10mL/kg and D-galactosamine 500 mg/kg in mice;Cirrhosis was induced by 40 ?l4 adding with variousagents in rats.The biochemical parameters such as serum ALT were examined and the histopathological changes of hepatic tissue was measured.Results Ganyu capsule could obviously inhibit the increase of serum ALT and AST activity and reduce the content of collagen in liver and the deseverity of hepatic fibrosis.Conclusion Ganyu capsule has protective effects on the acute and chronic hepatic injury in mice and rats. |
| Keywords: | Ganyu capsule Experimental hepatic injury Hepatoprotective action Pharmacodynamics |
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