| Antisense Smad2 inhibits high glucose-stimulated production of extracellular matrix in cultured rat glomerular mesangial cells |
| |
| 引用本文： | 郁胜强,赖凌云,马骥,顾勇,林善锬. Antisense Smad2 inhibits high glucose-stimulated production of extracellular matrix in cultured rat glomerular mesangial cells[J]. 中国人民解放军军医大学学报, 2005, 20(4): 204-208 |
| |
| 作者姓名： | 郁胜强 赖凌云 马骥 顾勇 林善锬 |
| |
| 作者单位： | Department of Nephrology，Changzheng Hospital，Second Military Medical University，Shanghai 200003，China，Department of Nephrology，Huashan Hospital，Fudan University，Shanghai 200040，China，Department of Nephrology，Huashan Hospital，Fudan University，Shanghai 200040，China，Department of Nephrology，Huashan Hospital，Fudan University，Shanghai 200040，China，Department of Nephrology，Huashan Hospital，Fudan University，Shanghai 200040，China |
| |
| 摘 要： | ![]()
Transforminggrowthfactor-β1(TGF-β1)is amultifunctionalpolypeptidethatregulatesanum-berofcellularprocesses,includingcellprolifera-tion,differentiation,apoptosis,migration,matrix synthesis,andtheimmuneresponse[1,2].Inchron-icrenaldiseases,TGF-β1isakeymediatorofex-tracellularmatrix(ECM)accumulation[3].Oneof thetargetrenalcellsforTGF-β1isglomerular mesangialcellsthatarecapableofproducingcom-ponentsofECM,suchascollagens,lamininand fibronectin[4,5].Recentstudiesindicatedthatinhi-bitionofT…
|
| 关 键 词： | Smad2 抑制作用 葡萄糖 细胞外矩阵 糖尿病 肾病 |
| 收稿时间： | 2004-08-16 |
| 修稿时间： | 2005-03-12 |
Antisense Smad2 inhibits high glucose-stimulated production of extracellular matrix in cultured rat glomerular mesangial cells |
| |
| YU Sheng-qiang ,LAI Ling-yun,MA Ji,GU Yong,LIN Shang-yan. Antisense Smad2 inhibits high glucose-stimulated production of extracellular matrix in cultured rat glomerular mesangial cells[J]. Journal of Medical Colleges of PLA(China), 2005, 20(4): 204-208 |
| |
| Authors: | YU Sheng-qiang LAI Ling-yun MA Ji GU Yong LIN Shang-yan |
| |
| Affiliation: | YU Sheng-qiang~ 1*,LAI Ling-yun~2,MA Ji~2,GU Yong~2,LIN Shang-yan~2 ~1Department of Nephrology,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China ~2Department of Nephrology,Huashan Hospital,Fudan University,Shanghai 200040,China |
| |
| Abstract: | ![]()
|
| |
| Keywords: | Smad2 antisense vector extracellular matrix |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
