The role of muscular trauma in the development of heterotopic ossification after hip surgery: An animal-model study in rats |
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| Institution: | 1. Department of Orthopedics and Trauma Surgery, University Medical Centre, Johannes Gutenberg-University, Mainz, Germany;2. Institute of Applied Structure- and Microanalysis, University Medical Centre, Johannes Gutenberg-University, Mainz, Germany;1. Department of Orthopaedic Surgery, Innsbruck Medical University, Anichstraße 35, Innsbruck, Austria;2. Department of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, Netherlands;3. Department of Experimental Orthopaedics, Innsbruck Medical University, Innrain 36, Innsbruck, Austria;4. Department of Orthopedics, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria;5. Department of Orthopedics and Trauma Surgery, University Medical Center Freiburg, Hugstetter Straße 55, Freiburg, Germany;1. Department of Neurosurgery, Alfred Hospital, 55 Commercial Road, Melbourne, VIC 3004, Australia;2. Department of Orthopaedics, Alfred Hospital, Melbourne, VIC, Australia;1. Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;2. Department of Orthopaedics and Traumatology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430000, China;3. Department of Orthopaedics and Traumatology, Queen Mary Hospital, the University of Hong Kong, Pok Fu Lam, Hong Kong;1. Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Japan;2. Department of Orthopaedic Surgery, National Hospital Organization, Chiba Medical Center, Japan;3. Department of Bioenvironmental Medicine Graduate School of Medicine Chiba University, Japan;4. Department of Orthopaedic Surgery, Chiba Children''s Hospital, Japan;5. Dept of Orthopaedic Surgery, Sainou Hospital, Japan;1. Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Republic of Korea;2. Department of Anesthesiology and Pain Medicine, Seoul Metropolitan Government Seoul National University, Boramae Medical Center, Seoul, Republic of Korea;3. Department of Anesthesiology and Pain Medicine, College of Medicine, Inha University, Incheon, Republic of Korea;4. Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seoul, Republic of Korea |
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| Abstract: | BackgroundHeterotopic ossification (HO), the formation of bone in soft tissues, is a frequent complication after surgery of the hip and the pelvis. Although the pathophysiological entities responsible for the formation of HO remain largely unclear, muscle trauma is alleged to play a central role in the pathogenic mechanisms underlying HO. However, for this observation, made by many surgeons for decades, no objective evidence has been provided yet.MethodsFifty male Wistar rats were subjected to surgery of the right hip. The femoral canal was reamed in three steps up to 2 mm. Animals formed 2 groups: in group 1 (25 animals) every effort was taken not to injure the muscles. In contrast, in the rats of group 2 (25 animals), an additional muscle lesion was created. Twelve weeks after surgery, the amount of heterotopic bone was assessed using micro-computed tomography, and classified using a modified Brooker classification system. A chi-square test was used to assess the statistical hypothesis comparing both groups.ResultsA significant higher amount of heterotopic bone was observed in animals that underwent additional muscular trauma.ConclusionAccording to our data, muscle trauma seems to play an important role in the development of HO after hip surgery. Hence, during surgery, particular care not to injure the surrounding muscular tissue should be taken. |
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| Keywords: | Heterotopic ossification Hip surgery Animal model Pelvic surgery Acetabular surgery Hip prosthesis |
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