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Engineered stabilization and structural analysis of the autoinhibited conformation of PDE4 |
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| Authors: | Peder Cedervall Ann Aulabaugh Kieran F. Geoghegan Thomas J. McLellan Jayvardhan Pandit |
| Affiliation: | Structural Biology and Biophysics Group, Worldwide Research and Development, Pfizer, Inc., Groton, CT, 06340 |
| Abstract: | |
| Keywords: | PDE4 cAMP hydrolysis acrodysostosis UCR1/2 phosphodiesterase regulation |