万古霉素衍生物的合成与活性研究进展

万古霉素是临床上治疗革兰氏阳性细菌感染的最后一道防线，但其耐药菌的出现使寻找抗该耐药菌的万古霉素衍生物具有重要意义。本文综合近十年来该领域的工作成果，介绍了万古霉素的抗菌机制，并按照万古霉素单体修饰、二聚体及万古霉素模拟物等三个方面对万古霉素衍生物进行介绍，并总结了衍生位点及基团与化合物抗菌活性之间的关系。

Recent advances in the study of synthesis and activity of vancomycin derivatives

Vancomycin was enlisted as a drug of the last resort for the treatment of resistant grampositive bacterial infections. However, the emergence of vancomycin-resistant bacteria has created an urgent need for new active analogues of vancomycin. Summing up the last ten years work of this field, the review introduced the antibiotic mechanism of vancomycin and summarized the vancomycin derivatives based on the modifications of vancomycin, dimmer of vancomycin and the vancomycin mimetics. The connection of modified location and function with antibacterial activity was also discussed.