静脉注射盐酸戊乙奎醚和阿托品用于开胸手术术前用药的对比研究

目的比较盐酸戊乙奎醚、阿托品用于开胸手术前用药的临床效果。方法80例ASAⅠ～Ⅱ级胸科择期全麻手术患者随机分为Ⅰ组（盐酸戊乙奎醚组，n=40）和Ⅱ组（阿托品组，n=40），麻醉诱导前30min静脉注射盐酸戊乙奎醚或阿托品0．01mg／kg，记录SBP、DBP、HR、SpO2、口干程度及腺体分泌变化。结果两组患者注药前SBP、DBP、HR、Sp02无明显差异（P〉0．05）。Ⅰ组注药后第10min和15min SBP略下降，与注药前基础值相比差异具有统计学意义（P〈0．05）。Ⅱ组患者于注药后1min、5min、10min、15min HR明显高于基础值（P〈0．05），HR、SBP均明显高于Ⅰ组（P〈0．05）；两组VAS评分在注药后15min、30min时高于注药前（P〈0．05），两组间比较差异无统计学意义（P〉0．05）；插管后各时点、拔管及拔管后1h腺体分泌量两组有显著差异（P〈0．05及P〈0．01）。结论盐酸戊乙奎醚作为胸科术前用药效果满意，抑制腺体分泌作用效果确切，维持心血管功能稳定，是胸科患者理想的术前用药。

Comparison of penehydidine hydrochloride and atropine used intravenously as premedication in patients undergoing thoracic surgery

Objective To compare the effects of penehyclidine hydrochloride and atropine used intravenously as premedication in patients undergoing thoracic surgery. Methods 80 ASA grade Ⅰ～Ⅱ patients undergoing elective thoracic surgery under general anesthesia were randomly allocated to one of two groups. GroupⅠ （n = 40） received penehyelidine hydrochloride 0.01mg/kg and group Ⅱ（n = 40） received atropine 0.01 mg/kg. Penehyclidines hydrochloride or atropines were administered 30 minutes before induction of general anesthesia. SBP,DBP,HR,SpO2 , dryness degree of oral cavity and the secretion change of salivary gland were recorded. Results The baseline SBP,DBP,HR,SpO： were not significantly different among groups （P 〉 0. 05 ）. SBP was found significantly lower than baseline at 10 min and 15 rain in group I （P 〈 0.05 ）. HR was significantly higher than the baseline at 1 rain,5 rain,10 min,15 min after medication in group Ⅰ （P 〈0. 05）, HR and SBP were obviously higher than those of group Ⅰ（ P 〈 0. 05 ）. VAS score were significantly higher than the baseline at 15 min, 30 min after medication in both groups（ P 〈 0. 05 ） , no statistically significant difference was found between the two groups （ P 〉 0. 05 ）. The secretion of salivary gland were significantly different at each point after intubation ,extubation and extubation 1 h in both groups （P 〈0. 05＆ P 〈 0.01 ）. Conclusion Penehyclidine hydrochloride can be used before general anesthesia satisfactorily, Inhibite the secretion of salivary gland effectively, has stability on cardiovascular function, it is a better choice of premedication for patients undergoing thoracic surgery.