同型半胱氨酸和B型脑钠肽在糖尿病肾病诊断中的应用

目的对2型糖尿病合并肾病患者的血清同型半胱氨酸（Hcy）水平和脑钠肽（BNP）水平进行测定,并探讨2项指标在临床诊断中的价值。方法回顾2011年6月至2013年6月在公安县人民医院进行治疗的102例糖尿病患者的病例。参照患者临床尿清蛋白排除率（UAER）水平分为糖尿病无肾病组（43例）和糖尿病合并肾病组（59例）。并选择50例健康体检者作为对照组。对3组的Hcy、BNP和UAER水平进行测定和对比分析。结果糖尿病合并肾病患者Hcy、BNP和UAER水平显著性高于糖尿病无肾病组患者和对照组,差异有统计学意义（P〈0.05）;糖尿病无肾病组患者Hcy、BNP和UAER水平略高于对照组,但差异无统计学意义（P＞0.05）。结论 2型糖尿病合并肾病组患者Hcy和BNP水平具有特异性,可作为临床诊断糖尿病状况的有效指标。

Clinical significance of homocysteine and B-type natriuretic peptide for the diagnosis of diabetic nephropathy

Objective To investigate the clinical significance of B-type natriuretic peptide（BNP）and homocysteine（Hcy）in the diagnosis of diabetic nephropathy（DN）.Methods A total of 102patient with diabetes mellitus,treated in this hospital from Jun.2011to Jun.2013,were enrolled and divided into non-DN group（43cases）and DN group（59cases）,according to urine albumin excretion rate（UAER）.Another 50healthy subjects were enrolled as control group.Levels of Hcy,BNP and UAER were compared between each group.Results The levels of BNP,Hcy and UAER in DN group were higher than non-DN group and control group（P〈0.05）.The levels of BNP,Hcy and UAER of non-DN group were not significant different with control group（P〉0.05）.Conclusion BNP and Hcy could be used as sensitive markers for early diagnosis of DN.