慢性牙周炎患者血浆β-防御素-3的检测及其临床意义

目的:揭示慢性牙周炎患者血浆β-防御素-3浓度的变化,探讨其与慢性牙周炎患病危险性的相关性.方法:收集慢性牙周炎患者作为牙周炎组,共78例.收集同期牙周健康者作为对照组,共40例.ELISA检测血浆β-防御素-3浓度.统计分析其与慢性牙周炎患病危险性的相关性.结果:协方差分析显示,牙周炎组血浆β-防御素-3浓度(87....

Determination of Plasma Beta-Defensin-3 Concentration in Patients with Chronic Periodontitis and its Clinical Significance

Objective Change of plasma beta-defensin-3 level was determined in patients with chronic periodontitis and its correlation with disease was evaluated.Methods 78 consecutive patients with chronic periodontitis and 40 healthy controls were enrolled into this study.Plasma beta-defensin-3 concentration was measured by ELISA.Its Correlation with disease was analyzed statistically.Results The plasma beta-defensin-3 level(87.3±39.5 pg/ml) in patients was significantly lower than that(152.8±29.9 pg/ml) in healthy controls(P<0.05).Spearman correlation coefficient showed that probing depth(r=-0.359,P<0.05),attachment loss(r=-0.317,P<0.05) and bleeding index(r=-0.301,P<0.05) were negatively related to plasma beta-defensin-3 level in the patients with chronic periodontitis.On a multivariate logistic regression,plasma beta-defensin-2 level(OR=0.391,95%CI=0.257~0.812,P<0.05) was an independent variable predicting chronic periodontitis.A receiver operating characteristic curve identified that a plasma beta-defensin-3 level<123.9 pg/ml predicted chronic periodontitis with 74.4% sensitivity and 70.0% specificity(area under curve=0.819,95%CI=0.763~0.855,P<0.001).Conclusion Decreased beta-defensin-3 is found after chronic periodontitis and low beta-defensin-3 may be independently associated with chronic periodontitis.