f/t-PSA比值对t-PSA在正常范围内的Pca患者早期诊断的临床意义

目的:研究前列腺特异性抗原游离与总量(f/t-PSA)比值对t-PSA在正常范围内前列腺癌(Pca)早期诊断的价值.方法:采用电化学发光免疫分析技术检测150例正常健康男性,106例t-PSA>4.0μg/L及22例t-PSA<4.0μg/L的Pca患者血清t-PSA和f-PSA并求出f/t-PSA比值,然后进行统计学...

Clinical Significance of f/t-PSA Ratio on Early Detection for Prostate Cancer Patients with Normal Range of PSA

Objective To investigate the value of f/t-PSA ratio on early detection for prostate cancer(Pca) patients with normal range of prostate specific antigens(PSA).Methods ①The serum free PSA and total PSA in 150 normal male volunteers(normal control),and 128 cases with Pca(106 cases with PSA>4.0μg/L,22 cases with PSA<4.0μg/L) were measured by electrochemiluminescence immunoassay.The ratios of f/t-PSA ratio were therefore obtained and analyzed respectively.Results The serum concentrations of t-PSA,f-PSA and f/t-PSA ratio were 1.39±1.15ng/ml,0.45±0.32ng/ml,0.38±0.16 in cases of normal control group respectively,33.14±21.97ng/ml,4.34±3.27ng/ml and 0.16±0.09ng/ml in 106 cases with PSA>4.0μg/L,2.72±1.23ng/ml,0.43±0.31ng/ml and 0.17±0.10ng/ml in 22 cases with PSA<4.0μg/L respectively.Significant difference of t-PSA,f/t-PSA ratio was observed between the normal control group and 22 Pca cases with <4.0μg/L(P<0.001).Compared with normal control group,significant difference of t-PSA,f-PSA was found in the group of 106 Pca cases with >4.0μg/L.The cut off of f/t-PSA ratios were ranked as <0.10,0.11~0.15,0.16~0.20,0.21~0.25,0.26~0.30,>0.31.The 77.27% and 74.53 prevalence of Pca were observed in patients with PSA<4.0μg/L,PSA>4.0μg/L individually when cutoff of f/t-PSA ratio was less than 0.20(P>0.05).Conclusion The analysis of f/t-PSA ratio is of great help for early detection of prostate cancer for patients with serum t-PSA>4.0μg/L and as low as <4.0μg/L.