肝硬化并发严重感染患者C反应蛋白、前降钙素测定的临床意义

目的:分析肝硬化并发严重感染时血清前降钙素、C反应蛋白的变化及其临床意义。方法:对25例肝硬化并发自发性细菌性腹膜炎和败血症的患者,测定其血清和腹水的前降钙素(PCT)和反应蛋白(CRP)。结果:合并严重感染时,PCT明显增高,增高幅度与感染程度呈正比,且与未合并感染者的差异有显著性(P<0.05);同时还发现PCT的增高与CRP的升高呈正相关。结论:PCT是诊断肝硬化并发严重感染的一个新型、敏感的实验室指标,对于鉴别感染与否,是否为细菌性感染具有较好的特异性。

Clinical Significance of Determination the Levels of Serum C-reactive Protein and Procalcitonin in Hepatocirrhosis Patients with Severe Infection

Objective:To analyse the levels of serum C-reactive protein(CRP) and procalcitonin(PCT) in hepatocirrhosis patients with severe infection. Methods:Sera from 28 hepatocirrhosis patients with spontaneous bacterial peritonitis and septicemia were assayed for detection of PCT and CRP. Results:PCT level elevated in severe infection patients,and there was significant difference in PCT between infection patients and non-infection patients(P =0.00).PCT was positively related with CRP. Conclusion:PCT is a new sensitive indicator for diagnosis of severe bacterial infection,and has good specificity for distinguish bacterial from non-bacterial infection.