| 地特胰岛素与甘精胰岛素治疗2型糖尿病患者的临床疗效比较 |
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| 引用本文： | 张彦彬,张耀芬.地特胰岛素与甘精胰岛素治疗2型糖尿病患者的临床疗效比较[J].临床荟萃,2011,26(24):2130-2131,2136. |
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| 作者姓名： | 张彦彬 张耀芬 |
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| 作者单位： | 1. 海军总医院内分泌科,北京,100048
2. 武警总医院干部病房三科,北京,100039 |
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| 摘 要： | 目的比较口服降糖药（OAD）控制不佳的2型糖尿病（T2DM）患者加用1天1次地特胰岛素或甘精胰岛素治疗后对血糖的影响。方法共入选40例T2DM患者，随机给予睡前注射地特胰岛素或甘精胰岛素治疗。治疗时间为12周，比较两组治疗前后空腹血糖（FPG）、糖化血红蛋白（HbA1c）、体质量的变化及低血糖的发生。结果治疗12周时与治疗前比较，地特胰岛素组和甘精胰岛素组的HbA1c和FPG均有明显下降（P〈0．01），FPG分别由11．41mmol／L和11．36mmol／L降至6．31mmol／L和6．54mmol／L，HbA1c分别由8．75％和9．17％降至7．41％和7．76％；治疗前后两组间差异无统计学意义。治疗前后地特胰岛素组和甘精胰岛素组的体质量增加分别为（-1．30±1．82）kg和（2．20±2．84）kg（P〈0．05）。两组各发生1例低血糖，发生率均为5．0％。结论OAD治疗不佳的T2DM患者，联合地特胰岛素或甘精胰岛素治疗，具有相似的血糖控制，但地特胰岛素组体质量增加少。
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| 关 键 词： | 糖尿病，2型 胰岛素，长效 体重变化 血红蛋白A，糖基化 |
Comparison of therapeutic effect of insulin detemir and insulin glargine for type 2 diabetes mellitus |
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| ZHANG Yan-bin,ZHANG Yao-fen.Comparison of therapeutic effect of insulin detemir and insulin glargine for type 2 diabetes mellitus[J].Clinical Focus,2011,26(24):2130-2131,2136. |
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| Authors: | ZHANG Yan-bin ZHANG Yao-fen |
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| Institution: | ZHANG Yan-bin1,ZHANG Yao-fen2 1.Department of Endocrinology,Navy General Hospital,Beijing 100048,China,2.Department of No.3 Cadre's Ward,General Hospital of Chinese People's Armed Police Forces,Beijing 100039 |
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| Abstract: | Objective To compare efficacy,safety and change in body mass after once-daily insulin detemir or insulin glargine added to oral antidiabetic drugs(OAD) in poorly controlled type 2 diabetes mellitus(T2DM) patients.Methods 40 T2DM patients with poor glycemic control by oral antidiabetic drugs were randomized into two groups,which were treated with detemir+ OAD and glargine + OAD for 12 weeks,respectively.The parameters measured before and after treatment included fasting plasma glucose(FPG),human glycated hem... |
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| Keywords: | diabetes mellitus type 2 insulin long-acting body weight changes hemoglobin A glycosylated |
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