血必净注射液对急危重症患者多器官功能障碍的阻断作用研究

目的探讨血必净注射液对急危重症患者全身炎症反应综合征（SIRS）和多脏器功能障碍综合征（MODS）阻断作用的临床意义。方法将120例急危重症患者APACHEⅡ评分〉13分,随机分为对照组（60例）和血必净治疗组（简称治疗组,60例）,观察入院后第1、3、7、10天血清肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）、IL-6含量,血常规,肝、肾功能及APACHEⅡ分值,ICU住院天数、病死率、发生MODS例数。结果治疗组治疗后第3、7、10天血清TNF-α、IL-1β及IL-6水平较对照组有不同程度下降（P〈0.05或P〈0.01）;第3、7天CRP较对照组明显下降（P〈0.01）。第3、7、10天血WBC、BPC、ALB、Tbil、Cr及ALT较对照组明显改善（P〈0.05或P〈0.01）。治疗组器官衰竭率、病死率、住ICU天数及第7、10天APACHEⅡ分值均低于对照组（P〈0.05）。结论血必净注射液可明显抑制血浆内毒素产生,下调促炎介质TNF-α、IL-1β及IL-6水平,改善微循环和组织灌注,保护重要脏器功能,阻断SIRS恶性发展及MODS形成。

Blocking effects of Xuebijing injection on multiple organ dysfunction syndrome of severe acute disease patients

Objective To investigate the clinical significance of blocking effects of Xuebijing injection on systemic inflammatory response syndrome（SIRS） and multiple organ dysfunction syndrome（MODS） of severe acute disease patients. Methods 120 severe acute disease patients were randomly divided into two groups： control group（n=60） and Xuebijing treatment group（n=60）.At 1,3,7,10 days after admission,the contents of TNF-α,IL-1β,IL-6,blood routine,liver and renal function,APACHE Ⅱscore,hospital stay in ICU,mortality rate and the number of MODS cases were observed. Results The expression of serum TNF-α,IL-1β,IL-6 in treatment group were significantly lower than that of control group at 3,7,10d after admission（P0.05 or P0.01）.Compared with control group,expression of CRP decreased at 3,7d（P0.01）.There were significantly improved of WBC,BPC,ALB,Tbil,Cr and ALT in treatment group compared with control group at 3,7,10d after admission（P0.05 or P0.01）.The occurrence rates of organ failure,hospital stay in ICU,mortality rate and APACHEⅡ score at 7,10d were lower than control group（P0.05）. Conclusion Xuebijing injection can inhibit the plasma endotoxin,significantly block the development of SIRS and MODS formed,down-regulate TNF-α,IL-1β and IL-6 and protect vital organ dysfunction,improve microcirculation and tissue perfusion and protect the function of important organs.