MMP-11在食管鳞状细胞癌组织中的表达水平及临床意义分析

目的：探讨基质金属蛋白酶-11（MMP-11）表达水平，及其与食管鳞状细胞癌（ESCC）的关系。方法采用免疫组织化学法检测36例ESCC 癌组织及其癌旁组织标本，以及9例正常食管组织MMP-11表达水平。结果 ESCC 癌组织、癌旁组织及正常食管组织MMP-11蛋白阳性表达率分别为69．4％（25/36）、25．0％（9/36）、22．2％（2/9）。癌旁组织和正常食管组织MMP-11蛋白阳性表达率低于癌组织（ P ＜0．05），癌旁组织和正常食管组织 MMP-11蛋白阳性表达率比较差异无统计学意义（ P ＞0．05）。就MMP-11阳性表达率而言，Ⅰ～Ⅱ期患者低于Ⅲ～Ⅳ期患者、T1～ T2期患者低于T3～ T4期患者、无淋巴转移的患者低于有淋巴转移的患者（P ＜0．05）。MMP-11表达水平与患者年龄、性别和肿瘤位置、直径、病理类型无关（P＞0．05）。结论 MMP-11蛋白可能参与了ESCC 的发生、发展，MMP-11蛋白高表达可能是促进ESCC 浸润转移的因素之一。

Expression and clinical significance of MMP-11 protein in esophageal squamous cell carcinoma

Objective To explore the correlation between matrix metalloproteinases-11（MMP-11） and esopha-geal squamous cell carcinoma（ESCC） .Methods Expression of MMP-11 protein was detected by immunohistochem-istry in 36 cases of ESCC tissues and tumor-adjacent tissues ,and 9 cases of normal esophageal tissues .Results Posi-tive expression rate of MMP-11 in ESCC tissues was higher than tumor-adjacent tissues and normal tissues ,which were 69 .4% （25/36） ,25 .0% （9/36） and 22 .2% （2/9） respectively（P〈0 .05） .Positive expression rates of MMP-11 protein in patients at T1 -T2 stage ,Ⅰ - Ⅱ stage and with nodal metastases were lower than patients at T3 -T4 stage ,Ⅲ - Ⅳ stage and without nodal metastases respectively （P〈0 .05） .No correlations were found between MMP-11 protein expression levels and age ,gender ,tumor location ,tumor diameter and degree of differentiation（P〉0 .05） . Conclusion Up-regulation of MMP-11 expression level might be involved in the development of ESCC ,which might play a promoting role in the invasion and metastasis of ESCC .