| 广州地区不良孕产史夫妇外周血异常核型分析 |
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| 引用本文： | 夏冰,叶长烂,张中芬,郑霖,江悦华,王捷. 广州地区不良孕产史夫妇外周血异常核型分析[J]. 中国优生与遗传杂志, 2011, 0(11): 34-35,33 |
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| 作者姓名： | 夏冰 叶长烂 张中芬 郑霖 江悦华 王捷 |
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| 作者单位： | 广州军区广州总医院; |
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| 摘 要： | 目的观察不良孕产夫妇异常染色体分布类型及其与不良孕产的关系。方法对261对不良孕产夫妇外周血淋巴细胞进行细胞遗传学分析,采用G显带方法。结果 261对不良孕产史夫妇染色体异常80例(15.3%),其中相互易位9例;Turner嵌合体1例;染色体异态70例,包括9号染色体小臂间倒位10例,次缢痕长度增加16例,D组、G组短臂的随体长度增加或减少或双随体共36例,大Y、小Y共8例。结论不良孕产夫妇染色体异常主要为平衡易位和多种染色体异态,后者在不良孕产史夫妇中的高发生率提示其具有一定临床效应。
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| 关 键 词： | 染色体畸变 染色体异态 不良孕产 |
Analysis of chromosome abnormality in 261 couples with aderverse pregnancy outcome history in Guangzhou |
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| XIA Bing,YE Chang-lan,ZHANG Zhong-fen,ZHENG Lin,JIANG Yue-hua,WANG Jie.. Analysis of chromosome abnormality in 261 couples with aderverse pregnancy outcome history in Guangzhou[J]. Chinese Journal of Birth Health & Heredity, 2011, 0(11): 34-35,33 |
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| Authors: | XIA Bing YE Chang-lan ZHANG Zhong-fen ZHENG Lin JIANG Yue-hua WANG Jie. |
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| Affiliation: | XIA Bing,YE Chang-lan,ZHANG Zhong-fen,ZHENG Lin,JIANG Yue-hua,WANG Jie.(Guangzhou General Hopital of Guangzhou Military Command,Guangzhou 510010,China) |
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| Abstract: | Objective:To explore the types of chromosome abnormality in the couples with aderverse pregnancy outcome history.Method:Cytogenetic analysis with G-staining method was performed on the peripheral blood lymphocyte cultures of 261 couples with abnormal pregnancy-labor history.Results: Chromosome abnormalities were found in 80 patients,including 9 of reciprocal translocation,1 mosaic Turner syndrome,70 of chromosome heteromorphism which included 10 of small pericentric inversion of chromosome 9,16 of increase ... |
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| Keywords: | Chromosomal abnormality Chromosome heteromorphism Adverse pregnancy outcome |
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