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| 内蒙古地区慢性粒细胞白血病患者HLA-DRB1基因多态性的研究 | |
| 引用本文： | 贺立新,云宇光,崔明玉,娜琴,陈阿梅. 内蒙古地区慢性粒细胞白血病患者HLA-DRB1基因多态性的研究[J]. 中国优生与遗传杂志, 2011, 0(1): 17-18 |
| 作者姓名： | 贺立新 云宇光 崔明玉 娜琴 陈阿梅 |
| 作者单位： | 内蒙古医学院第一附属医院超声科;内蒙古医学院组织学与胚胎学教研室; |
| 基金项目： | 内蒙古自然科学基金资助项目(2009MS1161) |
| 摘 要： | 目的为研究内蒙地区汉族人群人类白细胞抗原（human leukocyte antigen,HLA）DRB1基因与CML白血病的相关性。方法采用Luminex流式技术-序列特异性寡核苷酸探针反向杂交（flow cytometry-sequence specific oligonucle-otide probe,FLOW-SSOP）方法对内蒙地区39例慢性粒细胞白血病chronic myeloid leukemia,CML）患者HLA-DRB1等位基因多态性进行分析,以北方地区健康群体资料作为正常对照。结果在HLA-DRB1等位基因中,CML白血病组中DRB1＊1001,＊16XX等位基因频率高于对照组（0.593%,0.603%,P〈0.05）。结论 DRB1＊1001,DRB1＊16XX等位基因与CML相关联,可能是易感基因。 |
| 关 键 词： | HLA-DRB1 慢性粒细胞白血病 FLOW-SSOP |
Study the polymorphisms of HLA-DRB1,alleles in patient's with chronic myelogenous leukemia in Inner Mongolia |
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| HE Li-xin,YUN Yu-guang,CUI Ming-yu,NA Qin,CHEN A-mei.. Study the polymorphisms of HLA-DRB1,alleles in patient's with chronic myelogenous leukemia in Inner Mongolia[J]. Chinese Journal of Birth Health & Heredity, 2011, 0(1): 17-18 | |
| Authors: | HE Li-xin YUN Yu-guang CUI Ming-yu NA Qin CHEN A-mei. |
| Affiliation: | HE Li-xin,YUN Yu-guang,CUI Ming-yu,NA Qin,CHEN A-mei.(1.Department of Ultrasound,the Affiliated Hospital Inner Mongolia Medical College,2.Inner Monglia Medical College Huherhaoter,010059) |
| Abstract: | Objective: To explore the correlation between the HLA-DRB1,alleles and susceptibility to CML leukemia in Inner Mongolia.Methods: HLA-DRB1 alleles polymorphism in CML patient of 39 were examined with flow cytometry-sequence specific oligonucleotide probes (FlOW-SSOP) methods.2480 normal subjects in Northern China as control.Results: The frequencies of allele DRB1* 1001,HLA-DRB1* 16XX were increased (P < 0.05).Conclusion: DRB1* 1001,DRB1* 16XX alleles may be positive correlated with Leukemia. |
| Keywords: | HLA-DRB1 CML FLOW-SSOP |
| 本文献已被 CNKI 维普 等数据库收录！ | |