| 硫化氢对吗啡依赖大鼠空间学习记忆及海马NMDA受体表达的影响 |
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| 引用本文： | 秦伟,金寰,罗孝美,陈远寿.硫化氢对吗啡依赖大鼠空间学习记忆及海马NMDA受体表达的影响[J].遵义医学院学报,2011,34(5):453-456. |
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| 作者姓名： | 秦伟 金寰 罗孝美 陈远寿 |
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| 作者单位： | 遵义医学院生理学教研室,贵州遵义,563000 |
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| 基金项目： | 贵州省科技厅社会发展科技攻关计划项目(NO:20083066) |
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| 摘 要： | 目的探讨新型气体信号分子硫化氢（H2S）对吗啡依赖大鼠空间学习记忆及海马NMDA受体表达的影响。方法将大鼠随机分为对照组、依赖组、NaHS组和HA组,Morris水迷宫观察H2S对依赖大鼠空间学习记忆的影响;Western-blotting测定大鼠海马NMDA受体表达。结果在Morris水迷宫实验中,依赖组和HA组逃避潜伏期和空间搜索距离较生理盐水对照组延长（〈0.05）,NaHS组较依赖组大鼠逃避潜伏期短（〈0.05）,NaHS组与对照组比较无显著性差异（〉0.05）;在Western-blotting实验中,依赖组和HA组大鼠海马NMDA受体NR1亚基蛋白表达较对照组增多（〈0.05）,NaHS组大鼠海马NMDA受体NR1亚基蛋白表达较依赖组减少（〈0.05）。结论外源性H2S可减少NMDA受体NR1亚基蛋白表达,改善吗啡依赖大鼠空间学习记忆能力。
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| 关 键 词： | 硫化氢 吗啡依赖 学习记忆 NMDA受体 |
Effect of Hydrogen Sulfide on Spatial Learning and Memory and NMDA Receptor Expression of Hippocampus in Morphine-dependent Rats |
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| Qin Wei
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Jin Huan
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Luo Xiaomei
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Chen Yuanshou.Effect of Hydrogen Sulfide on Spatial Learning and Memory and NMDA Receptor Expression of Hippocampus in Morphine-dependent Rats[J].Acta Academiae Medicine Zunyi,2011,34(5):453-456. |
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| Authors: | Qin Wei Jin Huan Luo Xiaomei Chen Yuanshou |
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| Institution: | Qin Wei,Jin Huan,Luo Xiaomei,Chen Yuanshou(Department of physiology Zunyi Medical College,Zunyi,Guizhou,563000,China) |
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| Abstract: | Objective To explore the effects of Hydrogen sulfide(H2S),a recently discovered gaseous signaling molecule,on spatial learning and memory and NMDA receptor expression of hippocampus in morphine-dependent dependent rats.Methods Rats were randomly divided into 4 groups: control group,morphine-dependent group,NaHS group and hydroxylamine(HA) group.The effect of H2S on spatial learning and momery was behaviorally characterized by Morris water maze test.And the expression of NMDA receptor in rat hippocampus was ... |
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| Keywords: | Hydrogen sulfide morphine-dependent learning and memory NMDA receptor |
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