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Plasma concentrations of mianserin after single dose and at steady-state in depressed elderly patients
Authors:S Dawling  S Ford  P Ariyanayagam  H O'Neal  R R Lewis
Abstract:Plasma mianserin and desmethylmianserin concentrations were measured in 17 clinically depressed elderly patients after a single 30 mg dose of mianserin. The patients then received mianserin 30 mg daily for up to 6 weeks and the plasma concentrations were measured at weekly intervals. The relationship between concentrations of mianserin and desmethylmianserin at steady-state and at 16 and 24 hours after the single test dose was not good enough to be used for prediction of dosage requirements. Reasons for this finding are discussed.
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