银杏达莫与丹参川芎嗪注射液治疗老年急性心肌梗死的临床对照研究

目的 探讨银杏达莫与丹参川芎嗪注射液治疗老年急性心肌梗死的临床疗效。方法 选取60例老年急性心肌梗死患者，随机数字表法分为两组，均给予常规治疗，观察组患者（30例）在此基础上给予银杏达莫注射液治疗，对照组患者（30例）在此基础上给予丹参川芎嗪注射液治疗，根据疗效，治疗前后血液流变学指标及治疗期间不良反应情况，评价银杏达莫与丹参川芎嗪注射液治疗老年急性心肌梗死的临床疗效。结果 观察组治疗有效率86.7%，对照组治疗有效率90.0%，两组治疗急性心肌梗死的有效率差异无统计学意义。治疗前，两组血液黏度、红细胞压积、血小板聚集率相比，差异无统计学意义；治疗后两组血液黏度、红细胞压积和血小板聚集率均降低，同组治疗前后比较差异有统计学意义（P<0.05）；且观察组红细胞压积和血小板聚集率低于对照组，差异有统计学意义（P<0.05），但血液黏稠度治疗后两组没有明显差异。根据单个药品的花费成本以及治疗有效率，计算成本/效果比，可知银杏达莫注射液的成本/效果比值明显小于丹参川芎嗪注射液，差异有统计学意义（P<0.05）。治疗期间，两组不良反应率比较无明显差异。结论 银杏达莫与丹参川芎嗪注射液对老年急性心肌梗死均具有较好的治疗效果，药物安全性高，但银杏达莫注射液在抑制血小板聚集、降低红细胞压积方面作用较强，成本/效果值较低。

Clinical efficacy of Ginkgo Leaf Extract and Dipyridamole Injection and Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection in treatment of acute myocardial infarction

Objective To discuss the efficacy of Ginkgo Leaf Extract and Dipyridamole Injection and Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection in treatment of acute myocardial infarction. Methods 60 cases of acute myocardial infarction were randomly divided into two groups. They were treated with routine treatment. The observation group (30 cases) was treated with Ginkgo Leaf Extract and Dipyridamole Injection on the basis of routine treatment. The control group (30 cases) was treated with Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection on the basis of routine treatment. The efficacy of Ginkgo Leaf Extract and Dipyridamole Injection and Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection in treatment of acute myocardial infarction was evaluated by the efficacy, hemorheology before and after treatment, adverse reaction during treatment. Results The effective rate of observation group was 86.7%. The effective rate of control group was 90.0%. There was no statistical significance on effective rate between two groups. Before treatment, there were no statistical significance on blood viscosity, hematocrit, platelet aggregation rate between two groups. After treatment, the blood viscosity, hematocrit, platelet aggregation rate were decreased in two groups (P<0.05). The observation group of hematocrit and platelet aggregation rate was lower than the control group (P<0.05). But the blood viscosity of two groups had no significant difference. According to the cost and the efficiency of single drug treatment, calculate the cost/effect ratio, the Ginkgo Leaf Extract and Dipyridamole Injection of cost/effect ratio was significantly less than that of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection (P<0.05). During treatment, there was no statistical significance on adverse reaction rate between two groups. Conclusion Ginkgo Leaf Extract and Dipyridamole Injection and Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection had a therapeutic effect on acute myocardial infarction with high safety. The Ginkgo Leaf Extract and Dipyridamole Injection could inhibit the platelet aggregation, reduce the hematocrit with low cost/effect value.