93例转移性恶性黑色素瘤预后分析

目的:探讨转移性恶性黑色素瘤的预后因素。方法:回顾性分析93例经病理证实的转移性恶性黑色素瘤患者的临床资料及实验室、影像学检查结果。结果:93例转移性恶性黑色素瘤患者2年生存率为10.8%(10/93)。性别、体质状况、有无肝脏转移、转移部位数目、血清LDH水平、白蛋白水平以及转移灶是否切除对患者的2年生存率有显著影响;而不同年龄患者的2年生存率无统计学差异。结论:女性、体质状况较好、无肝脏转移、单一部位转移、LDH或白蛋白水平正常以及孤立转移病灶的手术切除是预后好的指标。

Prognostic Factors in Patients with Metastatic Malignant Melanoma

Objective : To determine clinical prognostic factors that accurately predict survival in patients with metastatic melanoma. Methods : 93 patients with metastatic malignant melanoma were analysed retrospectively. Results : 10.8% of all patients with distant metastasis of melanoma lived for more than 2 years. There was significant difference in 2-year survival rate between men and women,KPS≥80 and <80, liver and without liver involvement,one and multiple organ involvements, normal and elevated serum level of LDH, normal and decreased serum albumin, respectively. There was no difference between≥50 years and <50 years. Conclusion : Female, good performance status, without liver involvement, single organ metastase, normal LDH and albumin level, resection of the isolated focus are highly significant predictors of good survial.