脑利尿钠肽与早期糖尿病肾病的关系

目的探讨血清脑利尿钠肽（BNP）与早期糖尿病肾病（DN）的关系及其临床意义.方法随机选择非肥胖2型糖尿病病人64例,按尿微量清蛋白排泄率（UAER）分为早期DN组（DN＋组,UAER 20～200 μg/min,30例）和非DN组（DN-组,UAER〈20 μg/min,34例）;健康成人30例作为对照（CON）组.应用酶联免疫吸附法（ELISA）测定各组血清BNP水平.结果 DN-组血清BNP的水平明显高于CON组（F=6.82, q=4.30, P〈0.01）,DN＋组血清BNP的水平高于DN-组（q=4.80, P〈0.01）;且与UAER呈明显的正相关（r=0.85,P〈0.01）.结论早期DN病人血清BNP水平显著升高, 可能在DN的发生、发展过程中起重要作用.

RELATIONSHIP BETWEEN SERUM BRAIN NATRIURETIC PEPTIDE AND EARLY-STAGE DIABETIC NEPHROPATHY

ObjectiveTo investigate the relationship between the serum brain natriuretic peptide(BNP) and early-stage diabetic nephropathy,and to analyze its clinical significance.MethodsSixty-four patients with nonobese type 2 diabetes mellitus and 30 normal controls were studied.According to urinary albumin excretion rate(UAER),the 64 patients were divided into two groups,one with microalbuminuria(DN ) and the other with normoalbuminuria(DN-).The serum levels of BNP were measured with competitive Enzyme Immunoassay kit.ResultsThe serum levels of BNP were significantly higher(F=6.82,q=(4.30),P<0.01) in all the patients than those of normal subjects.The blood concentrations of BNP were significantly increased with microalbuminuria,compared with those with normoalbuminuria(F=6.82,q=(4.80),P<0.01).The serum levels of BNP were positively and significantly correlated with UAER(r=0.85,P<0.01) in diabetic nephropathy.ConclusionThe serum levels of BNP were significantly increased in patients with early-stage diabetic nephropathy,which probably play an important role in the occurrence and development of this disease.