|
|||||
|
|
| 门冬氨酸芦氟沙星的合成 | |
| 引用本文： | 景士云,柳丽新,牟春福. 门冬氨酸芦氟沙星的合成[J]. 沈阳药科大学学报, 2008, 25(7): 553-555 |
| 作者姓名： | 景士云 柳丽新 牟春福 |
| 作者单位： | 哈药集团制药总厂,黑龙江哈尔滨,150046 |
| 摘 要： | 目的合成喹诺酮类抗菌药门冬氨酸芦氟沙星。方法以9,10-二氟-7-氧-2,3-二氢-7H-吡啶并[1,2,3-de][1,4]苯并噻嗪-6-羧酸为起始原料,经螯合、取代、水解、成盐4步反应制得门冬氨酸芦氟沙星。结果制得门冬氨酸芦氟沙星,总收率为62.7%。结论该工艺适合工业化生产,为芦氟沙星的制剂研究提供了一个新的原料药。 |
| 关 键 词： | 门冬氨酸芦氟沙星 喹诺酮 药物合成 |
| 收稿时间： | 2007-12-10 |
Synthesis of rufloxacin aspartate |
|
| JING Shi-yun,LIU Li-xin,MU Chun-fu. Synthesis of rufloxacin aspartate[J]. Journal of Shenyang Pharmaceutical University, 2008, 25(7): 553-555 | |
| Authors: | JING Shi-yun LIU Li-xin MU Chun-fu |
| Affiliation: | (The General Pharmaceutical Factory of Harbin Pharmaceutical Group ,Harbin 150046,China) |
| Abstract: | Objective To synthesize rufloxacin aspartate, a new quinolone antibacterial drugs, by a new method. Methods Rufloxacin aspartate was synthesized from 9,10-difluoro-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acid via four steps. The target compound was prepared by means of chelation, substitution, hydrolysis and salt formation reaction. Result The total yield was 62.7%. Conclusion The synthetic method is suitable for industrial production. |
| Keywords: | rufloxacin aspartate quinolone synthesis |
| 本文献已被 维普 万方数据 等数据库收录！ | |
| 点击此处可从《沈阳药科大学学报》浏览原始摘要信息 | |
| 点击此处可从《沈阳药科大学学报》下载全文 | |