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| 高密度脂蛋白(HDL)抗动脉粥样硬化研究进展 | |
| 引用本文： | 董继斌. 高密度脂蛋白(HDL)抗动脉粥样硬化研究进展[J]. 复旦学报(医学版), 2012, 39(4): 414-417. DOI: 10.3969/j.issn.1672 8467.2012.04.017 |
| 作者姓名： | 董继斌 |
| 作者单位： | 复旦大学药学院生物化学教研室上海201203 |
| 摘 要： | 血浆高密度脂蛋白(high density lipoprotein,HDL)通过其载脂蛋白A I(apolipoprotein A I,ApoA I)介导胆固醇逆向转运,呈现抗动脉粥样硬化(atherosclerosis,AS)功能。近来大量研究结果显示高密度脂蛋白的多种抗AS、抗炎功能与胆固醇代谢无关,而是由其联结的鞘氨醇 1 磷酸(sphingosine 1 phosphate,S1P)和ApoA I分别通过S1P受体和清道夫受体B I(scavenger receptor class BI,SR BI)介导的细胞内信号通路来实现。 |
| 关 键 词： | 高密度脂蛋白(HDL) 载脂蛋白A I (ApoA I) 鞘氨醇 1 磷酸受体(S1P) 清道夫受体B I (SR BI) 动脉粥样硬化(AS) |
Research advances in anti-atherosclerosis of high-density lipoprotein (HDL) |
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| DONG Ji-bin. Research advances in anti-atherosclerosis of high-density lipoprotein (HDL)[J]. Fudan University Journal of Medical Sciences, 2012, 39(4): 414-417. DOI: 10.3969/j.issn.1672 8467.2012.04.017 | |
| Authors: | DONG Ji-bin |
| Affiliation: | Department of Biochemistry, School of Pharmacy, Fudan University, Shanghai 201203,China |
| Abstract: | It is well known that anti atherogenic actions of high density lipoprotein(HDL) are thought to be reverse cholesterol transport through its associated apolipoprotein A I (ApoA I). Recently mounting evidence indicates that multiple anti atherogenic or anti inflammatory actions of HDL independent of cholesterol metabolism are mediated by HDL associated sphingosine 1 phosphate (S1P) through S1P receptors and by ApoA I through scavenger receptor class BI (SR BI). |
| Keywords: | high density lipoprotein (HDL) apolipoprotein A I(ApoA I) sphingosine 1 phosphate (S1P) receptors scavenger receptor class BI (SR BI) atherosclerosis (AS) |
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