| 炎息康药效学的研究 |
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| 引用本文： | 魏伟,陈敏珠,徐叔云. 炎息康药效学的研究[J]. 中国药理学通报, 1986, 0(1) |
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| 作者姓名： | 魏伟 陈敏珠 徐叔云 |
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| 作者单位： | 安徽医科大学临床药理研究所(魏伟，陈敏珠)，安徽医科大学临床药理研究所(徐叔云) |
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| 摘 要： | 应用角叉菜诱导大鼠踝关肿节胀、二甲苯诱导小鼠耳水肿、大鼠佐剂性关节炎、酵母诱导大鼠发热、冰醋酸诱导小鼠扭体反应和小鼠“热板”法等实验模型,研究了炎息康的药理作用,并对其急性和亚急性毒性进行了系统观察。结果表明,炎息康有明显而较持久的抗炎、解熟和镇痛效应,其急性抗炎和镇痛作用(ED50分别为4和5.01mg/kg)类似于炎痛喜康和消炎痛。该药几乎无急性毒性。
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| 关 键 词： | 炎息康 药理作用 毒性反应 |
Pharmacological Effects of Isoxicam |
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| Wei Wei. Pharmacological Effects of Isoxicam[J]. Chinese Pharmacological Bulletin, 1986, 0(1) |
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| Authors: | Wei Wei |
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| Abstract: | The pharmacological effects of Isoxicam were studied by several models .Carrageenan-induced paw oedema,adjuvant-induced arthritis in rats, xylol-induced ear oedema in mice, yeast-induced fever in rats, and acetic acid-induced writhing in mice in comparison to piroxicam & indomethacin. Furthermore,its toxicology was systema tically examined. The results revealed that Isoxicam had a marked and prolonged antiinflammatory, antipyretic and analgesic activity. The acute antiinflammatory and analgesic activity(ED50,4 & 5.01mg /kg,respectively)was similar to piroxicam.It had less acute toxicity. The ventricular, hepatic and kidney's epithelic cells showed light degeneration at doses of 50~l50mg/kg/d for 3 months, but their functions were not affected. No pathological change was found after the adminstration of the drug had been discontinued for 3 months. |
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| Keywords: | Isoxicam Pharmacological activity Adverse effect |
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