不同分割剂量适形放疗对胰腺癌的疗效

目的应用立体适形放射治疗技术不同分割剂量治疗胰腺癌,观察其疗效和并发症。方法27例胰腺癌患者分两组进行立体适形放射治疗,两组病人病情相似,均用5个~8个共面或非共面适形固定野,A组13例:每天1次,每次2Gy~2.5Gy,每周共5次,总剂量60Gy~70Gy/35天~50天;B组14例:隔日1次,每次4Gy~8Gy,每周3次,总剂量40Gy~52Gy/14天~28天。结果A组:有胸背部疼痛患者88%明显缓解;放疗后6个月CT复查,肿瘤缩小25%以上者为53.8%;1年生存率为46.2%;B组:有胸背部疼痛患者85.7%明显缓解;放疗后6个月CT复查,肿瘤缩小25%以上者42.85%;1年生存率为35.7%。结论A组在胸背部疼痛缓解率、肿瘤缩小率及1年生存率略比B组高,经统计学处理,P>0.05,无统计学意义。常规分割和大分割立体适形两者放射治疗定位准确,治疗并发症少,能有效减轻患者疼痛,延长生存期。

Different three dimensional conformal radiotherapy technique for the treatment of pancreatic carcinoma

Objective To observe the effiacy and complications of three dimensional conformal radiotherapy (3DCRT) treating pancreatic carcinoma by different dosage fraction .Methods Twenty seven27 patients with pancreatic carcinoma were divided into two groups,A abnd B. Everybody were irradiated the same to 5 to 8 coplanarity or uncoplanarity at immobile wilds .In group A,13 patients were irradiated 2.0GY ~2.5GY/f,five times a week, totally 25~35times and does of 60GY to 70GY within 35~50 days . In group B ,14 patients were irradiated 4.0~8.0GY/f , every other day , three times a week, totally 6~12 times and dose of 40GY~50GY within 14~28 days.Result Ingroup A: the pain in patients' abdominal and back alleviated 88%. The tumour of 53.8% patients was smaller over 25% after 6 months. The survival rate of one year was 46.2%. IngroupB: the pain alleviated 85.7%, the tumour of 42.85% patients were smaller over 25%, and the 1-year survival rate was 35.7%.Conclusion No obvious difference is observed in companing the one year survival, pain alleviate and tumor being smaller between group A and B (P>0.05) . Conventional fraction radiotherapy (CFR) and hypofractionated radiotherapy(HOFRT) orientate correctly has little complications . In the treatment of pancreatic carcinoma the patients' pain can be released rapidly and the patients' survival can be improved.