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Exceptional Responders Inspire Change: Lessons for Drug Development From the Bedside to the Bench and Back
Authors:Nicole G. Chau  Jochen H. Lorch
Affiliation:Department of Medical Oncology, Dana‐Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA
Abstract:Targeted therapies have changed the landscape of cancer treatment, although they fail too many patients with advanced cancer. Still, insight gained from an exceptional responder has the power to identify new biomarkers of sensitivity that can unlock subsets of patients across anatomic disease sites who may also derive benefit and facilitate development of novel therapeutic strategies that may overcome resistance. The use of large-scale genomic profiling is a promising first step.
Keywords:Exceptional responders  Personalized medicine  Precision medicine  Drug development
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