HLA-DP-associated susceptibility to the optico-spinal form of multiple sclerosis in the Japanese |
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| Authors: | H. Ito K. Yamasaki Y. Kawano I. Horiuchi C. Yun Y. Nishimura J. Kira |
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| Affiliation: | Division of Immunogenetics, Department of Neuroscience and Immunology, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan;Second Department of Internal Medicine, Kumamoto University School of Medicine, Kumamoto, Japan;Department of Neurology, Neurological Institute, Faculty of Medicine, Kyushu University, Fukuoka, Japan;Department of Pediatrics, Nagasaki University School of Medicine, Nagasaki, Japan |
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| Abstract: | Abstract: We studied polymorphism of the HLA-DP gene in 46 patients with optico-spinal form (Asian type) multiple sclerosis (MS) showing recurrent opticomyelitis and 46 patients with Western type MS with disseminated central nervous system involvement. We previously reported a significant association between an HLA-DRB1 *1501- DRB5 * 0101 haplotype and susceptibility to Western type but not Asian type MS. In the present study, we found that the frequencies of DPAl * 0202 and DPB1 * 0501 alleles were significantly increased in patients with Asian type MS, as compared with findings in 92 healthy control subjects (91.3% vs 65.2%, P corr<0.05 and 89.1% vs 63.0%, P corr < 0.05 respectively), but not in Western type MS. Our data provide further evidence that Asian and Western type MS are distinct regarding the immunogenetic background. |
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| Keywords: | disease susceptibility HLA-DP Japanese population multiple sclerosis |
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