|
|||||
|
|
Vimentin expression by reed-Sternberg cells in Hodgkin's disease |
|
| Authors: | Carole A. Angel Ronald A. Cullen James H. Pringle Ian Lauder |
| Affiliation: | (1) Department of Pathology, The University of Sheffield Medical School, Beech Hill Road, PO Box 596, S10 2UL Sheffield, UK;(2) Department of Histopathology, Leicester Royal Infirmary, Leicester, UK;(3) Department of Pathology, The University of Leicester, Clinical Sciences Building, Leicester Royal Infirmary, Leicester, UK |
| Abstract: | Summary The expression of vimentin in Reed-Sternberg cells in 61 samples of Hodgkin's disease (HD) was examined using an avidin-biotin-peroxidase complex technique. Forty biopsies (66%) expressed vimentin, and expression was seen in all subtypes of HD. No immunophenotypic differences between vimentin-positive and vimentin-negative cases were noted. The significance of such expression is unclear, but may be related to the alterations in growth and differentiation that are typical of neoplastic cells. |
| Keywords: | Vimentin Reed-Sternberg cells Hodgkin's disease Immunohistology |
| 本文献已被 SpringerLink 等数据库收录！ | |