A multicenter study on clinical characteristics of Acinetobacter bacteremia in patients with liver cirrhosis |
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| Authors: | Chang-Pan Liu Tsung-Ta Chiang Yuag-Meng Liu Shu-Chen Kuo Ya-Sung Yang Yi-Tzu Lee Te-Li Chen Shou-Chuan Shih |
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| Affiliation: | 14. National Yang-Ming University Hospital, Yilan, Taiwan;15. Changhua Christian Hospital, Changhua, Taiwan;p. National Institute of Infectious Diseases and Vaccinology, National Health Research Institute, Miaoli County, Taiwan;q. MacKay Memorial Hospital, Taipei, Taiwan;r. Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan;s. Taipei Veterans General Hospital, Taipei, Taiwan;t. National Defense Medical Center, Taipei, Taiwan;1. Division of Infectious Diseases, Department of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan;2. Department of Medicine, MacKay Medical College, New Taipei City, Taiwan;3. MacKay College of Medicine, Nursing and Management, Taipei, Taiwan;4. Infection Control Committee, MacKay Memorial Hospital, Taipei, Taiwan;5. Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan;6. Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan;7. Division of Infectious Diseases, Department of Internal Medicine, Changhua Christian Hospital, Changhua County, Taiwan;8. National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli County, Taiwan;9. School of Medicine, National Yang-Ming University, Taipei, Taiwan;10. Department of Emergency Medicine, Taipei Veterans General Hospital, Taipei, Taiwan;11. Division of Infectious Diseases, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan;12. Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan;13. Division of Gastroenterology, Department of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan |
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| Abstract: | ![]()
BackgroundClinical characteristics and risk factors for mortality of Acinetobacter bacteremia in cirrhotic patients have not been investigated.MethodsAcinetobacter bacteremia cases from four medical centers were collected from 2009 to 2014, to compare between patients with and without liver cirrhosis. Risk factors for mortality of Acinetobacter bacteremia among cirrhotic patients were identified using multivariate logistic regression.ResultsAmong the patients with Acinetobacter bacteremia, 72 had liver cirrhosis and 816 had not. Patients with cirrhosis were younger (57.5 [50–71] vs. 72 [50.25–71], p < 0.001), had more solid tumor (51.4% vs. 31.4%, p = 0.001), lower Acute Physiology and Chronic Health Evaluation II (APACHE II) scores (17 [12–24] vs. 20 [13–28], p = 0.012), less sourced from pneumonia (19.4% vs. 35.8%, p = 0.008), and less caused by Acinetobacter baumannii (33.3% vs. 50.6%, p = 0.007) than those without. After matching for age, sex, and causative pathogens, the 30-day mortality (34.7% vs. 29.2%, p = 0.592) and APACHE II scores (17 vs. 17, p = 0.769) were not significant. APACHE II score (odds ratio [OR], 1.146; 95% confidence interval [CI], 1.035–1.268; p = 0.009), bacteremia caused by A. baumannii (OR, 20.501; 95% CI, 2.301–182.649; p = 0.007), and solid tumor (OR, 18.073; 95% CI, 1.938–168.504; p = 0.011) were independent risk factors for 30-day mortality of cirrhotic patients with Acinetobacter bacteremia.ConclusionEven though cirrhotic patients with Acinetobacter bacteremia were younger and had lower APACHE II scores than non-cirrhotic patients, the mortality rates were insignificantly different between the two groups. |
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| Keywords: | The ACTION Study Group Bacteremia Cirrhosis Mortality Risk |
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