Crocin ameliorates methotrexate-induced liver injury via inhibition of oxidative stress and inflammation in rats |
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| Authors: | Mojtaba Kalantar Heibatullah Kalantari Mehdi Goudarzi Layasadat Khorsandi Samira Bakhit Hadi Kalantar |
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| Affiliation: | 1. Student Research Committee, Shoushtar University of Medical Sciences, Shoushtar, Iran;2. Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;3. Department of Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;4. Medicinal Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;5. Cellular and Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran |
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| Abstract: | BackgroundMethotrexate (MTX) is used commonly in the treatment of various cancers and inflammatory diseases; nevertheless, the associated hepatotoxicity has limited its clinical application. Crocin (CRO) is described as a natural carotenoid with analgesic, antioxidant, and antiinflammatory properties. This study aimed to determine the effects of CRO on MTX-induced hepatotoxicity.MethodsFor pretreatment, CRO at doses of 25 and 50 mg/kg (po), as well as 20 mg/kg (ip) of MTX, was injected in rats.ResultsMTX led to hepatotoxicity, as confirmed by the significant increase in liver markers, histopathological changes, decreased GSH content, and reduced antioxidant enzyme activity (i.e., CAT, SOD, and GPx). It increased TNF-α, IL-1β, lipid peroxidation, and nitric oxide levels. Nevertheless, by increasing antioxidant defense in hepatic tissues and reducing oxidative stress and proinflammatory mediators, pretreatment with CRO could alleviate hepatotoxicity.ConclusionCRO can inhibit MTX-induced hepatotoxicity through improving antioxidant defense and reducing oxidative stress and inflammation. |
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| Keywords: | Corresponding author. Oxidative stress Inflammation Methotrexate Crocin Rat |
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