鱼油豆油对饲低硒粮大鼠体内含硒酶活力的影响

目的：研究富含多不饱和脂肪酸的鱼油和豆油对低硒大鼠体内含硒酶活力的影响。方法：饲大鼠低硒粮四周后添加鱼油或豆油（５０ｇ／ｋｇ）继续饲养四周，观察对大鼠肝、肾Ｔ４５－脱单碘酶（ＩＤ－Ｉ）和全血谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活力的影响。结果：低硒粮添加鱼油或豆油后，大鼠肝、肾ＩＤ－Ｉ活力降低，全血中ＧＳＨ－Ｐｘ活力亦明显降低；补充０．１μｇ／ｇ硒后可预防ＰＵＦＡｓ对二种酶活性的改变。结论：ＰＵ－ＦＡｓ（鱼油或豆油）可使机体缺硒状态加重。

TX THE EFFECT OF FISH OIL AND SOYBEAN OIL ON SELENOENZYME ACTIVITIES OF RATS FED ON SELENIUM DEFICIENT CEREALS

The　effect　of　fish　oil(FO)and　soybean　oil(SO)on　thyroxine　T4　5 monodeiodinase(ID I)and　glutathione　peroxidase(GSH Px)activities　in　rats　fed　on　selenium deficient　diets(0011μg/g)were　investigated.Rats　were　maintained　on　selenium deficient　diets　for 4 weeks　then　supplemented　with　FO　or　SO(50g/kg)for　4　weeks.The　results　showed　that　consumption　of　diets　supplemented　with　FO　or　SO　could　reduce　the　activities　of　ID I　in　liver　and　kidney,and　cause　a　significant　reduction　in　blood　GSH Px　activities.These　changes　could　be　effectively　prevented　by　means　of　sodium　selenite(0.1μg/g　Se)supplemention.The　results　indicate　that　polyunsaturated　fatty　acids　in　FO　or　SO　aggravate　the　status　of　selenium　deficiency　in　rat　fed　on　selenium deficient　diet.