EXPERIMENTAL WORK AND RESEARCH |
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作者姓名: | Yang Jun-wei |
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作者单位: | Yang Jun-wei(杨俊伟);and Li Lei-shi(黎磊石)(Institute of Nephrology,Jinling Hospital,Nanjing )(210002) |
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摘 要: | EXPERIMENTALWORKANDRESEARCHEffectsofRheumofficinaleontheRenalHypertrophyandHyperfiltrationintheStreptozotocin-InducedDiabetic...
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EXPERIMENTAL WORK AND RESEARCH Effects of Rheum officinale on the Renal Hypertrophy and Hyperfiltration in the Streptozotocin-Induced Diabetic Rats |
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Authors: | Yang Jun-wei |
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Abstract: | To study the effects of Rheum officinale (RO) on epidermal growth factor (EGF) in renalhypertrophy in the diabetic rats were induced by streptozotocin. The results showed that renal hypertro-phy occurred in the diabetic rats, but not in the RO-treated rats. Urine EGF was 38.2 16. 6 ng/24 h atday 28 in the control, and it was signiticantly increased from day 7 in the diabetic rats (477. 8 187. 2 ng/24 h at day 7, 328. 2 153. 9 ng/24 h at day 28) , while in the RO-treated rats it was significantly less thanthat in the diabetic rats (282. 2 112. 5 ng/24 h at day 7, 258. 3 72. 3 ng/24 h at day 28) . Moreover,glomerular filtration rate and renal blood flow reduced in RO-treated diabetic rats as compared with strep-tozotocin diabetic rats. Because kidney is the main source of urine EGF and EGF has been shown to in-duce renal growth both in vitro and in vivo. It is indicated that EGF may be able to initiate renal hypertro-phy in diabetic rats, and the effect of RO on the renal hypertrophy is probably relative to the inhibition ofrenal EGF production resulted from RO treatment. |
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Keywords: | kidney hypertrophy epidermal growth factor diabetic rat |
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