| 破骨细胞异质性的研究进展 |
| |
| 引用本文： | 万启龙,;李祖兵. 破骨细胞异质性的研究进展[J]. 中华口腔医学研究杂志(电子版), 2014, 0(6): 51-54 |
| |
| 作者姓名： | 万启龙, 李祖兵 |
| |
| 作者单位： | [1]武汉大学口腔医学院口腔基础医学省部共建国家重点实验室培育基地和口腔生物医学教育部重点实验室,430079; [2]武汉大学口腔医学院口腔颌面创伤与整形美容外科,430079; |
| |
| 基金项目： | 国家自然科学基金青年科学基金项目（81100736） |
| |
| 摘 要： | 破骨细胞是参与骨改建过程的关键细胞。近年来,越来越多的证据表明人体不同部位的破骨细胞生物学特性存在着差异,即破骨细胞异质性。但破骨细胞异质性的产生机制尚不明确,不同部位参与诱导破骨细胞形成的成骨细胞存在差异;不同部位破骨细胞所黏附的骨基质结构及组成成分不同;不同部位破骨前体细胞不同,可能是其产生的机制。
|
| 关 键 词： | 破骨细胞 异质性 成骨细胞 骨基质 破骨前体细胞 |
Research progress on osteoclast heterogeneity |
| |
| Affiliation: | Wan Qilong, LI Zubing.( The State Key Laboratory Breeding Base of Basic Science of Stomatology ( Hubei-MOST) ＆ Key Laboratory of Oral Biomedicine Ministry of Education, School ＆ Hospital of Stomatology, Department of Oral and Maxillofacial Trauma and Plastic Aesthetic Surgery, School ＆ Hospital of Stomatology, Wuhan University, Wuhan 430079, China) |
| |
| Abstract: | Osteoclasts play a key role in bone remolding. During the last decade, several studies have demonstrated the existence of bone-site-specific biological characteristics of osteoclasts,which is defined as osteoclast heterogeneity. However, the mechanism of such heterogeneity is, still unclear. There are three hypotheses that could explain osteoclast heterogeneity. First, osteoclast heterogeneity may be due to differences in the osteoblasts that harbor the different bone sites and are involved in the generation of osteoclasts. Second, the heterogeneity may be induced by differences in the composition of the bone where osteoclasts attach to. Third, osteoclast heterogeneity results from different osteoclast precursors. |
| |
| Keywords: | Osteoclast Heterogeneity Osteoblast Bone substrate Osteoclast precursors |
| 本文献已被 维普 等数据库收录！ |
|
