系统性红斑狼疮患者感染结核分枝杆菌后血清免疫指标变化及临床意义

目的探讨系统性红斑狼疮患者感染结核分枝杆菌后免疫功能的变化及临床意义。方法将本院收治的120例系统性红斑狼疮患者按照是否感染结核分枝杆菌分为观察组（感染者）67例和对照组（未感染者）53例,分别检查两组患者的血常规、风湿病组合及免疫组合指标,并将检查结果进行对比。结果观察组患者抗-核酸抗原（ANA）显著低于对照组,且抗-Sm、抗-抗干燥综合征A（SSA）、抗-抗干燥综合征B（SSB）阳性率均显著低于对照组（P均〈0.05）;而两组间抗-ds-DNA差异无统计学意义（P〉0.05）。观察组患者补体C3、C4水平显著升高,升高水平显著高于对照组（P均〈0.05）;而两组患者免疫球蛋白Ig G、Ig A和Ig M水平差异无统计学意义（P均〉0.05）。观察组血小板水平显著高于对照组,组间差异具有统计学意义（t=10.621,P〈0.05）。结论合并结核分支杆菌感染的系统性红斑狼疮患者体内免疫功能发生改变,抑制了系统性红斑狼疮的活动性,减轻了血液系统的损伤。

The serum immune indexe level changes and their clinical significance of systemic lupus erythematosus patients with Mycobacterium tuberculosis infection

Objective To explore the serum immune indexe level changes and their clinical significance of systemic lupus erythematosus patients infected with Mycobacterium tuberculosis. Methods Total of 120 cases with systemic lupus erythematosus in our hospital, according to whether with Mycobacterium tuberculosis infection were divided into the observation group（67 cases） and control group（53 cases）, the two groups were examined for blood, rheumatism and immune combination combination, and the inspection results were compared, respectively. Results The positive rates of antinuclear antibody（ANA） and anti-Sm, anti-SSA, anti-SSB in observation group were significantly lower than that in control group（P 〈0.05）; and the level of anti-ds-DNA in the two groups had significant difference（P 〉0.05）. The levels of complements C3 and C4 in observation group were significantly increased（P 〈0.05）; and levels of immunoglobulins Ig G, Ig A, Ig M in the two groups showed no significant difference（P〉 0.05）. The level of platelet in the observation group was significantly higher than that in the control group, with significant difference（t = 10.621, P 〈0.05）. Conclusions The immunological function changes in patients with systemic lupus erythematosus combined infection with tuberculosis, inhibited the activity of systemic lupus erythematosus, and also reduce the blood system damage.