光学相干断层扫描血管成像观察正常人中心凹无血管区的影响因素

目的:采用光学相干断层扫描血管成像(OCT-A)测量正常人中心凹无血管区(FAZ)的面积及中心凹相关指标，分析影响FAZ面积的因素。方法:横断面研究。将郑州市第二人民医院2015年12月至2016年5月53名志愿者纳入研究，其中男24人，女29人，年龄19～53(31.7±8.3)岁。每人均行各项有关眼科检查。采用Pe...

The influencing factors of foveal avascular zone in normal human eyes by optical coherence tomography angiography

Objective To analyze the influence factors of the area of foveal avascular zone(FAZ)and related indexes of fovea measured with optical coherence tomography angiography(OCT-A)in normal subjects.Methods This was a cross-sectional study.Fifty-three subjects from Dec.2015 to May 2016 in Zhengzhou Municipal Sceond People's Hospital were recruited in the study,including 24 males and 29 females,aged 19-53 years,with an average of(31.7±8.3)years.Each subject received related eye examination.The correlation between all the factors and FAZ were analyzed under Pearson’s correlation analysis.Results The area of FAZ was 0.13-0.57 mm^2,with an average of(0.35±0.11)mm^2.In Pearson’s correlation analysis,FAZ area was positively correlated with crest to crest distance(CC)of foveal retina(r=0.484,P<0.001),full width half maximum(FWHW)(r=0.642,P<0.001),and foveal depth(FD)(r=0.428,P=0.001).The area of FAZ was negatively correlated with central macular thickness(CMT)(r=0.408,P=0.002),foveal photoreceptor thickness(FPT)(r=0.393,P=0.004)and fovea blood flow density(FBFD)(r=0.876,P=0.000).The area of FAZ was not related with age,gender,spherical refraction and maximum retinal thickness(MaxRT)(P=0.467,0.967,0.334,0.735).Conclusion The area of FAZ was not affected by age,gender,diopter and MaxRT,but related to the shape of fovea,FBFD and CMT.