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| 精神分裂症早期的脑白质和灰质信号强度下降 | |
| 引用本文： | 魏钦令,范玉华,王相兰,康庄,张晋碚,国效峰,韩自力,赵靖平. 精神分裂症早期的脑白质和灰质信号强度下降[J]. 中国神经精神疾病杂志, 2010, 36(11) |
| 作者姓名： | 魏钦令 范玉华 王相兰 康庄 张晋碚 国效峰 韩自力 赵靖平 |
| 作者单位： | 1. 中南大学湘雅二医院精神卫生研究所,长沙,410011;中山大学附属第三医院精神科 2. 中山大学附属第一医院神经科 3. 中山大学附属第三医院精神科 4. 中山大学附属第三医院放射科 5. 中南大学湘雅二医院精神卫生研究所,长沙,410011 |
| 基金项目： | "十五"国家科技攻关基金资助项目，国家自然科学基金青年项目，广东省自然科学基金项目 |
| 摘 要： | 目的分析精神分裂症早期阶段脑灰质和脑白质结构的变化。方法对25例早期阶段(病程小于6个月)的首发未用药的精神分裂症患者和28名正常对照的脑部进行磁共振T1加权成像,所得图像以统计参数图软件包进行预处理,再对两组脑灰质密度和白质信号强度进行t检验。结果患者组左侧岛叶区(x=34,y=18,z=-2,体素集合数=163)、左枕叶(x=14,y=-66,z=14,体素集合数=76)、右侧额叶(x=46,y=44,z=8,体素集合数=74)白质信号强度较正常对照组降低(t=-3.78,P=0.007;t=-3.36,P=0.02;t=3.26,P=0.03);右侧枕叶(x=10,y=-84,z=8,体素集合数=64)脑灰质信号强度比正常对照组降低(t=3.12,P=0.03)。结论精神分裂症早期阶段即存在脑实质结构异常,以白质为著。 |
| 关 键 词： | 精神分裂症 脑灰质 脑白质 磁共振成像 统计参数图 |
The decrease of white matter and gray matter density in the early stage of first episode schizophrenia |
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| WEI Qinling,FAN Yuhua,WANG Xianglan,KANG Zhuang,ZHANG Jinbei,GUO Xiaofeng,HAN Zili,ZHAO Jingping. The decrease of white matter and gray matter density in the early stage of first episode schizophrenia[J]. Chinese Journal of Nervous and Mental Diseases, 2010, 36(11) | |
| Authors: | WEI Qinling FAN Yuhua WANG Xianglan KANG Zhuang ZHANG Jinbei GUO Xiaofeng HAN Zili ZHAO Jingping |
| Affiliation: | WEI Qinling,FAN Yuhua,WANG Xianglan,KANG Zhuang,ZHANG Jinbei,GUO Xiaofeng,HAN Zili,ZHAO Jingping. The Institute of Mental Health,Second Xiangya Hospital,Central South University,139 Rinmin Middle Road,Changsha. 410011. CHINA. |
| Abstract: | Objective To investigate whether structural abnormalities are present in the whole gray matter or white matter in early stage of schizophrenia. Methods Twenty-five patients in the early stage (with the course of less than 6 months) of first-episode-schizophrenia and 28 healthy controls were examired with T1 weighted magnetic resonance imaging. Scans were normalized,uniformed segmented and smoothed using the statistical parametric mapping 5 (SPM5),and the gray matter and white matter densities were compared ... |
| Keywords: | Schizophrenia Gray matter White matter Magnetic resonance imaging Statistical parametric mapping |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |