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| 抑癌基因p16突变与乳腺癌的相关研究 | |
| 引用本文： | 谢明,李建平. 抑癌基因p16突变与乳腺癌的相关研究[J]. 中国现代医药杂志, 2007, 9(4): 5-7 |
| 作者姓名： | 谢明 李建平 |
| 作者单位： | 423000,湖南郴州,湘南学院基础医学部病理学教研室 |
| 摘 要： | 目的研究乳腺癌p16基因的状态。方法采用多重PCR分析法,单链构像多态性分析法(SSCP)对48例乳腺癌标本与相应的癌旁组织中p16基因突变情况进行了检测。结果48例乳腺癌标本中16例p16基因第2外显子缺失,相应的癌旁组织未检出。结论p16基因在乳腺癌中存在高频率缺失,其改变与乳腺癌发生发展有着密切联系。 |
| 关 键 词： | 乳腺癌 p16基因 多重PCR 缺失 突变 |
| 文章编号： | 24342082 |
| 修稿时间： | 2007-01-04 |
Abnormality gene and its mutation in nasopharyngeal carcinoma |
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| Xie Ming,Li Jianping. Abnormality gene and its mutation in nasopharyngeal carcinoma[J]. Modern Medicine Journal of China, 2007, 9(4): 5-7 | |
| Authors: | Xie Ming Li Jianping |
| Affiliation: | Deportment of Pathogoly of the Basic Medical Dept. XiangNan University, Chenzhou, Hunan 423000 |
| Abstract: | Objective To investigate the status of p16 gene in breast cancer.Methods A total of 48 breast cancer samples and correspondent tumor-adjacent were detected for p16 gene mutations by using multiplex polymerase chain reaction(PCR)and single strand conformational polymorphism(SSCP)respectively.Result among 48 breast cancer samples,16 cases homozygous deletions and mutation were no identified.However,deletion and mutation were not found in all the tumor-adjacent tissues.Conclusion The data above show that p16 gene loss in high frequency in breast cancer.The alteration of p16 gene may play an important role in breast cancer . |
| Keywords: | Breast cancer P16 gene Multiplex PCR deletions Mutation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |