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Child-Pugh,MELD, and ALBI scores for predicting the in-hospital mortality in cirrhotic patients with acute-on-chronic liver failure |
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| Authors: | Ying Peng Shanhong Tang Han Deng Jing Li Zheng Ning |
| Institution: | 1. Liver Cirrhosis Study Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, China;2. Postgraduate College, Dalian Medical University, Dalian, China;3. Department of Digestion, General Hospital of Chengdu Military Command, Chengdu, China;4. Disease Preventive and Control Center, Chengdu Military Command, Chengdu, China |
| Abstract: | Objectives: Our study aimed to evaluate the discriminative abilities of Child-Pugh, model for end-stage liver disease (MELD), and albumin-bilirubin (ALBI) scores in predicting the in-hospital mortality in cirrhotic patients with acute-on-chronic liver failure (ACLF). Methods: Cirrhotic patients with ACLF admitted between 2010 January and 2014 June were retrospectively reviewed. Areas under the receiver operating characteristic curves (AUROCs) with 95% confidence intervals (CIs) were calculated. Results: One hundred patients were eligible for the Asia-Pacific Association for the Study of the Liver (APASL) criteria. AUROCs of Child-Pugh, MELD, and ALBI scores in predicting the in-hospital mortality was 0.63 (95%CI: 0.52–0.72, P = 0.05), 0.75 (95%CI: 0.65–0.83, P < 0.0001), and 0.53 (95%CI: 0.42–0.63, P = 0.69), respectively. Eighty-eight patients were eligible for the EASL/AASLD criteria. AUROCs of Child-Pugh, MELD, and ALBI scores in predicting the in-hospital mortality were 0.59 (95%CI: 0.48–0.69, P = 0.14), 0.57 (95%CI: 0.46–0.68, P = 0.26), and 0.57 (95%CI: 0.46–0.67, P = 0.29), respectively. There was no significant difference among them. Conclusion: Child-Pugh, MELD, and ALBI scores might be ineffective in predicting the in-hospital mortality of cirrhosis with ACLF. |
| Keywords: | ACLF ALBI prognosis mortality cirrhosis |