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寻常型银屑病皮损中细胞周期蛋白A、D1、B1和E的表达
引用本文:刘厚君,吴艳,林能兴,刘志香,李家文,涂亚庭. 寻常型银屑病皮损中细胞周期蛋白A、D1、B1和E的表达[J]. 中国麻风皮肤病杂志, 2007, 23(2): 98-100
作者姓名:刘厚君  吴艳  林能兴  刘志香  李家文  涂亚庭
作者单位:华中科技大学同济医学院附属协和医院皮肤科,武汉,430022
摘    要:目的:探讨细胞周期蛋白A(Cyclin A)、Cyclin B1、Cyclin D1和Cyclin E在寻常型银屑病皮损中的表达和意义。方法:采用免疫组化法对28例寻常型银屑病患者的皮损和18例正常人对照皮肤中的Cyclin A、D1、B1和E的表达进行了检测。结果:28例寻常型银屑病患者中26例皮损表达Cyclin A和Cyclin B1,27例有Cyclin D1和Cyclin E表达,正常组织无表达或弱表达。结论:细胞周期蛋白A、D1、B1和E可能通过诱导细胞增殖参与了银屑病的发病。

关 键 词:银屑病  细胞周期蛋白  免疫组化
收稿时间:2006-03-27
修稿时间:2006-03-272006-05-20

Expression of Cyclin A, D1, B1 and E in skin lesion of patients with psoriasis vulgaris
Liu Houjun, Wu Yan, Lin Nengxing,et al.. Expression of Cyclin A, D1, B1 and E in skin lesion of patients with psoriasis vulgaris[J]. China Journal of Leprosy and Skin Diseases, 2007, 23(2): 98-100
Authors:Liu Houjun   Wu Yan   Lin Nengxing  et al.
Affiliation:Liu Houjun, Wu Yan, Lin Nengxing,et al. Department of Dermatology,Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan,430022)
Abstract:Objective:To investigate the expression of Cyclin A,B1,D1 and E in psoriatic skin lesions.Methods:The expression of Cyclin A,D1,B and E in the skin lesions of 28 patients with psoriasis vulgaris was measured by immunohistochemical technique.Normal skin from 18 healthy persons was used as negative control.Results:The positive expression of Cyclin E and D1 were observed in 27 cases and positive staining of Cyclin A and CyclinB1 was detected in 26 cases with psoriasis vulgaris,whereas,there was no expression or week expression of Cyclin A,D1,B1 and E in control group.Conclusion:Cyclin A,D1,B1 and E may be involved in the pathogenesis of psoriasis by inducing the keratinocyte proliferation.
Keywords:psoriasis   Cyelin  immunohistochemistry
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