| 乳腺癌基因表达谱研究进展 |
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| 引用本文： | 于建刚. 乳腺癌基因表达谱研究进展[J]. 国际肿瘤学杂志, 2010, 37(4). DOI: 10.3760/cma.j.issn.1673-422X.2010.04.017 |
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| 作者姓名： | 于建刚 |
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| 作者单位： | 福建医科大学基础医学院生物化学与分子生物学系,福州,350014 |
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| 摘 要： | 乳腺癌是分子表达差异显著的一组疾病,乳腺癌临床异质性源自分子异质性.根据基因表达谱研究开发的分子标签,如70-基因标签、21-基因标签、乳腺癌分子分型标签等,在预测乳腺癌患者预后、指导临床治疗决策方面,表现出良好的应用价值和前景.
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| 关 键 词： | 乳腺肿瘤 基因表达谱 预后 |
Advances in gene expression profiling of breast cancer |
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| YU Jian-gang. Advances in gene expression profiling of breast cancer[J]. Journal of International Oncology, 2010, 37(4). DOI: 10.3760/cma.j.issn.1673-422X.2010.04.017 |
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| Authors: | YU Jian-gang |
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| Abstract: | Breast cancer should be considered as a family of diseases which are significantly different from each other in molecule level rather than a single disease, and clinical heterogeneity of breast cancer origins from molecular heterogeneity. Gene-expression signatures have been developed based on gene expression profiling of breast cancer, such as the 70-gene signature, 21 -gene signature and intrinsic subtypes of breast cancer. These signatures are valuable and have a good prospect in prognosis predicting and clinical decision of breast cancer. |
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| Keywords: | Breast neoplasms Gene expression profiling Prognosis |
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