黄芩苷脂质载体凝胶的制备及其体外透皮性能评析

目的:制备黄芩苷脂质体凝胶与传递体凝胶,同时比较两者体外释透皮性能.方法:以卡波姆981为辅料制备黄芩苷脂质体凝胶与传递体凝胶,采用改良Franz扩散池,以离体小鼠皮肤为透皮屏障,紫外分光光度法测定黄芩苷的单位面积累积透皮量.结果:黄芩苷脂质体凝胶与传递体凝胶24 h单位面积累积透皮量分别为(38.00±2.51),(43.27±2.39) μg·cm-2,体外释药特性均符合Higuchi动力学方程.结论:在无压力条件下,黄芩苷传递体凝胶与普通脂质体凝胶具有相似的体外透皮性能.

Preparation of Baicalin Lipid Carrier Gel and Evaluation of its in vitro Transdermal Property

Objective:To prepare baicalin liposome gel and transfersome gel,and to compare in vitro transdermal property of them.Method: Baicalin liposome gel and transfersome gel were prepared with carbopol 981 as accessories,modified Franz diffusion cell was used,isolated rat skin as transdermal barrier,unit area cumulative permeation quantity of baicalin was determined by ultraviolet spectrophotometry.Result: Unit area cumulative permeation quantities of baicalein liposome gel and transfersome gel in 24 h were(38.00±2.51),(43.27±2.39)μg·cm-2 respectively,in vitro transdermal property of them were in line with Higuchi pharmacokinetics equation.Conclusion: Without pressure,baicalin transfersome gel had similar in vitro tansdermal property with ordinary liposome gel.