Role of gene polymorphisms/haplotypes and serum levels of interleukin-17A in susceptibility to viral myocarditis |
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| Authors: | Hui Tang Hua Pei Qianfeng Xia Yimei Tang Ji Huang Jie Huang Fang Pei |
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| Affiliation: | 1. Department of Cardiology, People''s Hospital of Shuangqiao Economic and Technological Development Zone, Chongqing, China;2. Laboratory of Tropical Biomedicine and Biotechnology, Hainan Medical University, Haikou, China;3. Department of Cardiology, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China;4. Department of Cardiology, Chongqing Municipal Corps Hospital of Chinese People''s Armed Police Force, Chongqing, China |
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| Abstract: | ![]()
Interleukin-17A (IL-17A) has been implicated in the pathogenesis of viral myocarditis (VMC). However, the role of IL-17A polymorphisms in susceptibility to VMC has not been reported to date. The aim of this study was to explore the association between IL-17A variants as well as serum IL-17 levels with VMC. Three single-nucleotide polymorphisms (SNPs) (rs2275913, rs3819025, and rs3748067) were analyzed by the polymerase chain reaction-restriction fragment length polymorphism method in 236 VMC patients and 259 controls from China. Serum IL-17A levels were measured by enzyme-linked immunosorbent assay kits. Multivariable logistic regression analysis that the rs2275913 AA genotype and the haplotype -197A/+45G/+1249G (AGG) were associated with an increased risk of VMC (all P?P?P?P?P?
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| Keywords: | Viral myocarditis Interleukin (IL)-17A Polymorphism |
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