氨基糖苷类药物在重度感染患者中的应用

氨基糖苷类药物主要用于敏感需氧革兰阴性杆菌所致感染治疗。因耳毒性和肾毒性等不良反应,使其在临床上、尤其是在重度感染中的应用受到较大限制。但氨基糖苷类药物属静止期杀菌剂,对常见革兰阴性杆菌如铜绿假单胞菌、肺炎克雷伯菌和大肠埃希菌等的抗生素后效应较长、杀菌作用完全,在治疗需氧革兰阴性杆菌和阳性菌所致重度感染治疗中有着不可替代的作用。

The application of aminoglycoside antibiotics in severe infections

Aminoglycoside antibiotics are a class of antibacterial agents having the structure of amino sugar and aminocyclitol,which is effective against the infections caused by the sensitive aerobic Gram-negative bacilli.Because of its side effects of ototoxicity and nephrotoxicity and so on,it is restricted in the clinical usage especially in severe infections.But the aminoglycoside antibiotics are a quiescent bactericide.It has longer post antibiotic effect on the common Gram-negative bacilli such as Pseudomonas aeruginosa,Klebsiella pneumonia,Escherichia coli and complete bactericidal action.So aminoglycoside antibiotics play an irreplaceable role in treatment of severe infections caused by aerobic Gram-negative bacilli and positive bacteria.