中心性肥胖与糖调节受损、2型糖尿病的关系

目的探讨以腰臀比(waist-to-hip ratio,WHR)为指标的中心性肥胖与空腹血糖受损、糖耐量异常和2型糖尿病(type 2 diabetes,T2DM)发病的关系。方法采用队列研究,对684名社区居民追踪随访3年后,运用单因素及多因素Logistic回归分析中心性肥胖与糖调节受损(impaired glucose regulation,IGR)及T2DM发病的关系。结果WHR异常者发生IGR和T2DM的风险分别是正常者的2.32(95%CI:1.65~3.26)倍和2.48(95%CI:1.09~5.63)倍;控制混杂因素后,WHR异常组发生IGR(RR=1.60,95%CI:1.14~2.23)和T2DM(RR=1.89,95%CI:1.21~2.36)的风险仍然比WHR正常组高。结论中心性肥胖是IGR及T2DM发病的危险因素。

The relationship between central obesity,impaired glucose regulation and type 2 diabetes mellitus

Objective To explore the relationship between central obesity indicated by waist - to - hip ratio, impaired fasting glucose, impaired glucose tolerance and type 2 diabetes mellitus （DM）. Methods A cohort study was conducted a- mong 684 community residents who were followed up for three years. An univariate and multivariate logistic regression was used to analyze the relationship between central obesity, impaired glucose regulation （IGR） and type 2 DM. Results Individuals with abnormal waist - to - hip ratio were 2.32 times （ 95 % CI ： 1.65 - 3.26 ） and 2.48 times （ 95 % CI： I. 09 - 5.63） respectively higher than those with normal waist - to - hip ratio at risk for IGR and type 2 DM. After the control of confoun- ding factors, those with abnormal WHR still had a higher risk of developing IGR and type 2 DM than those without[ RR = 1.60,95%CI：1.14 -2.23）vs. （RR = 1.89,95% Cl：l. 21 -2.36） ]. After controlling ,the RRs wereand） respectively. Conclusions Central obesity is a risk factor of IGR and type 2 DM.