Biphasic relaxation caused by electrical field stimulation of the mesenteric arteries of rats. |
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| Authors: | R Saito K Handa S Tanaka A Fukumitsu K Honda Y Takano H Kamiya |
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| Affiliation: | Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan. |
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| Abstract: | Electrical field stimulation (EFS) caused biphasic relaxation, first transient and then sustained, of rat mesenteric arteries precontracted by prostaglandin (PG) F2alpha. The transient relaxation was reduced about 45%, and the sustained relaxation was not observed after endothelium denudation of the arteries. N(omega)-Nitro-L-arginine (L-NOARG) inhibited the biphasic relaxation induced by EFS. At 1 - 100 microM, L-NOARG inhibited the transient relaxation more than the sustained relaxation. Methylene blue inhibited the biphasic relaxation and at 100 microM, L-NOARG abolished the transient relaxation. These results suggest that the transient relaxation mainly involves nitric oxide (NO), whereas the sustained relaxation involves both NO and some other factor(s). |
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