| 丹酚酸A对大鼠心肌缺血再灌注性损伤的保护作用 |
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| 引用本文： | 杜冠华,裘月,张均田. 丹酚酸A对大鼠心肌缺血再灌注性损伤的保护作用[J]. 药学学报, 1995, 30(10): 731-735 |
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| 作者姓名： | 杜冠华 裘月 张均田 |
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| 作者单位： | 中国医学科学院，中国协和医科大学药物研究所 |
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| 摘 要： | 用Langendorff离体大鼠心脏缺血再灌注模型,研究了丹酚酸A(SalA)对心肌缺血再灌注性损伤的保护作用。结果显示,SalA可以降低由于心肌缺血再灌注引起的室颤发生率,减少乳酸脱氢酶(LDH)从胞体中的漏出,降低缺血心肌组织中脂质过氧化产物MDA的含量,从而证明SalA对离体大鼠心肌缺血再灌注性损伤具有一定的保护作用。
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| 关 键 词： | 丹酚酸A 心肌缺血再灌注 心室纤颤 |
| 收稿时间： | 1994-12-22 |
PROTECTIVE EFFECT OF SALVIANOLIC ACID A ON ISCHEMIA- REPERFUSION INDUCED INJURY IN ISOLATED RAT HEART |
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| GHDu,Y Qiu and JT zhang. PROTECTIVE EFFECT OF SALVIANOLIC ACID A ON ISCHEMIA- REPERFUSION INDUCED INJURY IN ISOLATED RAT HEART[J]. Acta pharmaceutica Sinica, 1995, 30(10): 731-735 |
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| Authors: | GHDu Y Qiu JT zhang |
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| Abstract: | The protective effect of salvianolic acid A(Sal A )on cardiac ischemia- reperfusioninduced injury was studied on the isolated rat heart.The results indicate that SaL A can reduce theoccurence of ventricular fibrillation,decrease the cellular LDH leaking and reduce the concentration oflipid peroxidation preduct- MDA significantly in ischemia-reperfused cardiac tissue. The possiblemachenism in decreasing ischemia-reperfusion injury of Sal A was discussed. |
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| Keywords: | Salvianolic acid A Cardiac ischemia-reperfusion Ventricular fibrillation |
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